Impact of nutrient excess on physiology and metabolism of

Sulfolobus acidocaldarius archaea carbon overfeeding chemostat cultivation fatty acid metabolism overflow metabolism parsimonious flux balance analysis transcriptomic analysis

Journal

Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977

Informations de publication

Date de publication:
2024
Historique:
received: 03 08 2024
accepted: 13 09 2024
medline: 21 10 2024
pubmed: 21 10 2024
entrez: 21 10 2024
Statut: epublish

Résumé

Overflow metabolism is a well-known phenomenon that describes the seemingly wasteful and incomplete substrate oxidation by aerobic cells, such as yeasts, bacteria, and mammalian cells, even when conditions allow for total combustion via respiration. This cellular response, triggered by an excess of C-source, has not yet been investigated in archaea. In this study, we conducted chemostat cultivations to compare the metabolic and physiological states of the thermoacidophilic archaeon

Identifiants

pubmed: 39430106
doi: 10.3389/fmicb.2024.1475385
pmc: PMC11486757
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1475385

Informations de copyright

Copyright © 2024 Sedlmayr, Széliová, De Kock, Gansemans, Van Nieuwerburgh, Peeters, Quehenberger, Zanghellini and Spadiut.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Auteurs

Viktor Laurin Sedlmayr (VL)

Research Division Biochemical Engineering, Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Vienna, Austria.

Diana Széliová (D)

Department of Analytical Chemistry, University of Vienna, Vienna, Austria.

Veerke De Kock (V)

Research Group of Microbiology, Department of Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.

Yannick Gansemans (Y)

Department of Pharmaceutics, Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium.

Filip Van Nieuwerburgh (F)

Department of Pharmaceutics, Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium.

Eveline Peeters (E)

Research Group of Microbiology, Department of Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.

Julian Quehenberger (J)

Research Division Biochemical Engineering, Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Vienna, Austria.

Jürgen Zanghellini (J)

Department of Analytical Chemistry, University of Vienna, Vienna, Austria.

Oliver Spadiut (O)

Research Division Biochemical Engineering, Institute of Chemical, Environmental and Bioscience Engineering, TU Wien, Vienna, Austria.

Classifications MeSH