Inhibition of monoamine oxidases by heterocyclic derived conjugated dienones: synthesis and

Journal

RSC medicinal chemistry
ISSN: 2632-8682
Titre abrégé: RSC Med Chem
Pays: England
ID NLM: 101759460

Informations de publication

Date de publication:
12 Sep 2024
Historique:
received: 07 08 2024
accepted: 11 09 2024
medline: 21 10 2024
pubmed: 21 10 2024
entrez: 21 10 2024
Statut: aheadofprint

Résumé

A total of 18 heterocyclic derived conjugated dienones (CD1-CD18) were evaluated for their potential monoamine oxidase (MAO)-A/-B inhibitory activity. Among the analyzed molecules, CD11 and CD14 showed notable inhibitory potentials against MAO-B, with half-maximal inhibitory concentration (IC

Identifiants

DOI: 10.1039/d4md00608a PMID: 39430951 PMC: PMC11487422
pubmed: 39430951
doi: 10.1039/d4md00608a
pii: d4md00608a
pmc: PMC11487422
doi:

Types de publication

Journal Article

Langues

eng

Informations de copyright

This journal is © The Royal Society of Chemistry.

Déclaration de conflit d'intérêts

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Sunil Kumar (S)

Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham AIMS Health Sciences Campus Kochi 682 041 India bijomathew@aims.amrita.edu bijovilaventgu@gmail.com.

Bishnu Prasad Pandey (BP)

Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University Suncheon 57922 Republic of Korea hoon@sunchon.ac.kr.
Department of Chemical Science and Engineering, Kathmandu University PO Box No. 6250 Dhulikhel 45200 Nepal.

Mohamed A Abdelgawad (MA)

Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University Sakaka 72341 Aljouf Saudi Arabia.

Mohammed M Ghoneim (MM)

Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University Ad Diriyah Riyadh 13713 Saudi Arabia.

Rania B Bakr (RB)

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Beni-Suef University Beni-Suef 62514 Egypt.

Hoon Kim (H)

Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University Suncheon 57922 Republic of Korea hoon@sunchon.ac.kr.
ORCID: 0000-0002-7203-3712

Bijo Mathew (B)

Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham AIMS Health Sciences Campus Kochi 682 041 India bijomathew@aims.amrita.edu bijovilaventgu@gmail.com.
ORCID: 0000-0002-6658-4497

Classifications MeSH