Preclinical pharmacology of patient-derived extracellular vesicles for the intraoperative imaging of tumors.

Extracellular Vesicles Animals Humans Indocyanine Green / administration & dosage Mice Neoplasms / diagnostic imaging Tissue Distribution Fluorescent Dyes Female
Bench-to-bedside Translation EV Biodistribution Kinetics Intraoperative Imaging Toxicology

Journal

Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395

Informations de publication

Date de publication:
2024
Historique:
received: 20 05 2024
accepted: 14 08 2024
medline: 21 10 2024
pubmed: 21 10 2024
entrez: 21 10 2024
Statut: epublish

Résumé

Extracellular vesicles (EVs) derived from the plasma of oncological patients exhibit significant tumor-targeting properties, unlike those from healthy individuals. We have previously shown the feasibility of formulating the near-infrared (NIR) fluorescent dye indocyanine green (ICG) with patient-derived extracellular vesicles (PDEVs) for selective delivery to neoplastic tissue. This staining protocol holds promise for clinical application in intraoperative tumor margin imaging, enabling precise neoplastic tissue resection. To this end, we propose the ONCOGREEN protocol, involving PDEV isolation, ICG loading, and reinfusion into the same patients.

Identifiants

DOI: 10.7150/thno.98671 PMID: 39431003 PMC: PMC11488097
pubmed: 39431003
doi: 10.7150/thno.98671
pii: thnov14p6301
pmc: PMC11488097
doi:

Substances chimiques

Indocyanine Green IX6J1063HV
Fluorescent Dyes 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

6301-6318

Informations de copyright

© The author(s).

Déclaration de conflit d'intérêts

Competing Interests: The authors have declared that no competing interest exists.

Auteurs

Alessandro Villa (A)

Department of Health Sciences, University of Milan, Milan, Italy.

Daniela Crescenti (D)

Department of Health Sciences, University of Milan, Milan, Italy.

Zemira De Mitri (Z)

Department of Health Sciences, University of Milan, Milan, Italy.

Elisabetta Crippa (E)

Department of Health Sciences, University of Milan, Milan, Italy.

Silvia Rosa (S)

Department of Health Sciences, University of Milan, Milan, Italy.

Nicoletta Rizzi (N)

Department of Pharmaceutical Sciences, University of Milan, Milan, Italy.

Fereshteh Shojaei-Ghahrizjani (F)

Department of Health Sciences, University of Milan, Milan, Italy.

Monica Rebecchi (M)

Department of Health Sciences, University of Milan, Milan, Italy.

Simona Vincenti (S)

Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

Francesca Selmin (F)

Department of Pharmaceutical Sciences, University of Milan, Milan, Italy.

Electra Brunialti (E)

Department of Health Sciences, University of Milan, Milan, Italy.

Nicolò Simonotti (N)

Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

Marianna Maspero (M)

Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.

Michele Dei Cas (M)

Department of Health Sciences, University of Milan, Milan, Italy.

Camilla Recordati (C)

Department of Veterinary Medicine and Animal Sciences, University of Milan, Milan, Italy.

Saverio Paltrinieri (S)

Department of Veterinary Medicine and Animal Sciences, University of Milan, Milan, Italy.

Alessia Giordano (A)

Department of Veterinary Medicine and Animal Sciences, University of Milan, Milan, Italy.

Rita Paroni (R)

Department of Health Sciences, University of Milan, Milan, Italy.

Margherita Galassi (M)

HPB Surgery and Liver Transplantation, Istituto Nazionale Tumori IRCCS Foundation (INT), Milan, Italy.

Vito Ladisa (V)

HPB Surgery and Liver Transplantation, Istituto Nazionale Tumori IRCCS Foundation (INT), Milan, Italy.

Flavio Arienti (F)

HPB Surgery and Liver Transplantation, Istituto Nazionale Tumori IRCCS Foundation (INT), Milan, Italy.

Francesco Cilurzo (F)

Department of Pharmaceutical Sciences, University of Milan, Milan, Italy.

Vincenzo Mazzaferro (V)

Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
HPB Surgery and Liver Transplantation, Istituto Nazionale Tumori IRCCS Foundation (INT), Milan, Italy.

Paolo Ciana (P)

Department of Health Sciences, University of Milan, Milan, Italy.

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Classifications MeSH

questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › Preclinical pharmacology of patient-derived...
questionsmedicales.fr › Eucaryotes › Animaux › Preclinical pharmacology of patient-derived...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Preclinical pharmacology of patient-derived...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Vert indocyanine › Preclinical pharmacology of patient-derived...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Preclinical pharmacology of patient-derived...
questionsmedicales.fr › Tumeurs › Preclinical pharmacology of patient-derived...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Preclinical pharmacology of patient-derived...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Luminescents › Colorants fluorescents › Preclinical pharmacology of patient-derived...