Nigrostriatal tract defects in mice with aromatic l-amino acid decarboxylase deficiency.
Aromatic l-amino acid decarboxylase deficiency
Dopamine deficiency
Nigrostriatal tract
Striatum
Substantia nigra
Journal
Neurobiology of disease
ISSN: 1095-953X
Titre abrégé: Neurobiol Dis
Pays: United States
ID NLM: 9500169
Informations de publication
Date de publication:
19 Oct 2024
19 Oct 2024
Historique:
received:
21
07
2024
revised:
08
10
2024
accepted:
16
10
2024
medline:
22
10
2024
pubmed:
22
10
2024
entrez:
21
10
2024
Statut:
aheadofprint
Résumé
The development of the nigrostriatal dopaminergic (DA) pathway in the brain involves many transcriptional and chemotactic molecules, and a deficiency of these molecules can cause nigrostriatal tract defects. However, the role of the end product, dopamine, in nigrostriatal pathway development has not been described. In the present study, we analyzed a mouse model of congenital dopamine and serotonin deficiency, namely, the aromatic l-amino acid decarboxylase (AADC) deficiency (Ddc
Identifiants
pubmed: 39433135
pii: S0969-9961(24)00307-3
doi: 10.1016/j.nbd.2024.106707
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106707Informations de copyright
Copyright © 2024. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no financial interests or personal relationships that may be considered potential competing interests.