Glucose impacts onto the reciprocal reprogramming between mammary adipocytes and cancer cells.

Humans Adipocytes / metabolism Glucose / metabolism Breast Neoplasms / metabolism Female Coculture Techniques Mesenchymal Stem Cells / metabolism Cellular Reprogramming Cell Differentiation Transcriptome Tumor Microenvironment Cell Line, Tumor
Adipogenesis Breast Cancer Glucose Mammary Adipocytes Transcriptional signatures Tumor Microenvironment

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
21 Oct 2024
Historique:
received: 13 03 2024
accepted: 15 10 2024
medline: 22 10 2024
pubmed: 22 10 2024
entrez: 21 10 2024
Statut: epublish

Résumé

An established hallmark of cancer cells is metabolic reprogramming, largely consisting in the exacerbated glucose uptake. Adipocytes in the tumor microenvironment contribute toward breast cancer (BC) progression and are highly responsive to metabolic fluctuations. Metabolic conditions characterizing obesity and/or diabetes associate with increased BC incidence and mortality. To explore BC-adipocytes interaction and define the impact of glucose in such dialogue, Mammary Adipose-derived Mesenchymal Stem Cells (MAd-MSCs) were differentiated into adipocytes and co-cultured with ER

Identifiants

DOI: 10.1038/s41598-024-76522-7 PMID: 39433816
pubmed: 39433816
doi: 10.1038/s41598-024-76522-7
pii: 10.1038/s41598-024-76522-7
doi:

Substances chimiques

Glucose IY9XDZ35W2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

24674

Subventions

Organisme : European Foundation for the Study of Diabetes
ID : EFSD/Lilly Research Fellowship Programme 2016/0052351
Organisme : Ministero dell'Università e della Ricerca
ID : PRIN 2022 - n. 2022KTJLHL
Organisme : Ministero dell'Università e della Ricerca
ID : P2022LPJM4
Organisme : Regione Campania
ID : POR FESR 2014-2020 - COEPICA
Organisme : Regione Campania
ID : POR FESR 2014-2020 - COEPICA
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG2023/29378

Informations de copyright

© 2024. The Author(s).

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Auteurs

Maria Rosaria Ambrosio (MR)

Institute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research (IEOS-CNR), Naples, Italy. mariarosaria.ambrosio@cnr.it.

Michiel Adriaens (M)

Maastricht Center for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands.

Kasper Derks (K)

Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.

Teresa Migliaccio (T)

Department of Translational Medicine (DiSMeT), University of Naples "Federico II", Naples, Italy.

Valerio Costa (V)

Institute of Genetics and Biophysics "A. Buzzati Traverso", National Council of Research (IGB-CNR), Naples, Italy.

Domenico Liguoro (D)

Institute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research (IEOS-CNR), Naples, Italy.

Simona Cataldi (S)

Institute of Genetics and Biophysics "A. Buzzati Traverso", National Council of Research (IGB-CNR), Naples, Italy.

Vittoria D'Esposito (V)

Institute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research (IEOS-CNR), Naples, Italy.

Giovanni Maneli (G)

Department of Translational Medicine (DiSMeT), University of Naples "Federico II", Naples, Italy.

Rita Bassolino (R)

Department of Translational Medicine (DiSMeT), University of Naples "Federico II", Naples, Italy.

Simone Di Paola (S)

Institute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research (IEOS-CNR), Naples, Italy.

Marinella Pirozzi (M)

Institute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research (IEOS-CNR), Naples, Italy.

Fabrizio Schonauer (F)

Department of Public Health, University of Naples "Federico II", Naples, Italy.

Francesco D'Andrea (F)

Department of Public Health, University of Naples "Federico II", Naples, Italy.

Francesco Beguinot (F)

Institute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research (IEOS-CNR), Naples, Italy.
Department of Translational Medicine (DiSMeT), University of Naples "Federico II", Naples, Italy.

Ilja Arts (I)

Maastricht Center for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands.

Pietro Formisano (P)

Institute of Experimental Endocrinology and Oncology "G. Salvatore", National Council of Research (IEOS-CNR), Naples, Italy. fpietro@unina.it.
Department of Translational Medicine (DiSMeT), University of Naples "Federico II", Naples, Italy. fpietro@unina.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Glucose impacts onto the reciprocal...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Adipocytes › Glucose impacts onto the reciprocal...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glucose impacts onto the reciprocal...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Glucose impacts onto the reciprocal...
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de coculture › Glucose impacts onto the reciprocal...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Glucose impacts onto the reciprocal...
questionsmedicales.fr › Phénomènes génétiques › Reprogrammation cellulaire › Glucose impacts onto the reciprocal...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Glucose impacts onto the reciprocal...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Glucose impacts onto the reciprocal...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Glucose impacts onto the reciprocal...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Glucose impacts onto the reciprocal...