Streptomyces sp. from desert soil as a biofactory for antioxidants with radical scavenging and iron chelating potential.
Streptomyces
/ chemistry
Soil Microbiology
Iron Chelating Agents
/ pharmacology
Antioxidants
/ pharmacology
Humans
RNA, Ribosomal, 16S
/ genetics
Free Radical Scavengers
/ chemistry
Phenols
/ chemistry
Tannins
/ pharmacology
Iron
/ metabolism
Desert Climate
Flavonoids
/ pharmacology
Cell Survival
/ drug effects
Alkaloids
/ pharmacology
Streptomyces
Actinomycetes
Antioxidant
Extremophiles
Iron chealtion
Journal
BMC microbiology
ISSN: 1471-2180
Titre abrégé: BMC Microbiol
Pays: England
ID NLM: 100966981
Informations de publication
Date de publication:
21 Oct 2024
21 Oct 2024
Historique:
received:
15
02
2024
accepted:
14
10
2024
medline:
22
10
2024
pubmed:
22
10
2024
entrez:
21
10
2024
Statut:
epublish
Résumé
Iron homeostasis is vital for normal physiology, but in the majority of circumstances, like iron overload, this equilibrium is upset leading to free iron in the plasma. This condition with excess iron is known as hemochromatosis, which has been linked to many side effects, including cancer and liver cirrhosis. The current research aimed to investigate active molecules from Streptomyces sp. isolated from the extreme environment of Bahawalpur deserts. The strain was characterized using 16 S rRNA sequencing. Chemical analysis of the ethyl acetate cure extract revealed the presence of phenols, flavonoids, alkaloids, and tannins. Multiple ultraviolet (UV) active metabolites that were essential for the stated pharmacological activities were also demonstrated by thin layer chromatography (TLC) and high-performance liquid chromatography (HPLC). Additionally, Gas chromatography/mass spectrometry (GC-MS) analysis revealed the primary constituents of the extract to compose of phenol and ester compounds. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay was used to assess the extract's antioxidant capacity, and the results showed a good half-maximal inhibitory concentration (IC
Identifiants
pubmed: 39434054
doi: 10.1186/s12866-024-03586-w
pii: 10.1186/s12866-024-03586-w
doi:
Substances chimiques
Iron Chelating Agents
0
Antioxidants
0
RNA, Ribosomal, 16S
0
Free Radical Scavengers
0
Phenols
0
Tannins
0
Iron
E1UOL152H7
Flavonoids
0
Alkaloids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
419Informations de copyright
© 2024. The Author(s).
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