Vascular inflammaging: Endothelial CEACAM1 expression is upregulated by TNF-α via independent activation of NF-κB and β-catenin signaling.
Aging
CEACAM1
NF‐κB
TNF‐α
endothelium
inflammation
β‐catenin
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
21 Oct 2024
21 Oct 2024
Historique:
revised:
01
09
2024
received:
08
03
2024
accepted:
25
09
2024
medline:
22
10
2024
pubmed:
22
10
2024
entrez:
22
10
2024
Statut:
aheadofprint
Résumé
Chronic inflammation with progressive age, called inflammaging, contributes to the pathogenesis of cardiovascular diseases. Previously, we have shown increased vascular expression of the Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in aged mice and humans, presumably via mutual upregulation with the pro-inflammatory cytokine TNF-α. CEACAM1 is critical for aging-associated vascular alterations like endothelial dysfunction, fibrosis, oxidative stress, and sustained inflammation and can be regarded as a main contributor to vascular inflammaging. This study was conducted to elucidate the mechanisms underlying endothelial CEACAM1 upregulation by TNF-α in detail. Using wildtype (WT) and TNF-α knockout (Tnf
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14384Subventions
Organisme : German Research Foundation
ID : 502291066
Organisme : German Research Foundation
ID : TRR221 B11
Organisme : German Research Foundation
ID : 324392634
Organisme : Vogel Foundation Dr. Eckernkamp/"Universitätsbund Würzburg", Würzburg, Germany
Informations de copyright
© 2024 The Author(s). Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.
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