Neonatal SARS-CoV-2 mRNA Vaccination Efficacy Is Influenced by Maternal Antibodies.
Female
Animals
Mice
Spike Glycoprotein, Coronavirus
/ immunology
Antibodies, Viral
/ immunology
SARS-CoV-2
/ immunology
Pregnancy
COVID-19
/ prevention & control
COVID-19 Vaccines
/ immunology
Animals, Newborn
Immunoglobulin G
/ blood
Vaccination
Immunity, Maternally-Acquired
Nanoparticles
Humans
RNA, Messenger
/ immunology
mRNA Vaccines
/ immunology
Liposomes
SARS‐CoV‐2
mRNA vaccination
maternal antibodies
neonatal immunity
pregnancy
vertical transmission
Journal
American journal of reproductive immunology (New York, N.Y. : 1989)
ISSN: 1600-0897
Titre abrégé: Am J Reprod Immunol
Pays: Denmark
ID NLM: 8912860
Informations de publication
Date de publication:
Oct 2024
Oct 2024
Historique:
revised:
20
09
2024
received:
05
08
2024
accepted:
30
09
2024
medline:
22
10
2024
pubmed:
22
10
2024
entrez:
22
10
2024
Statut:
ppublish
Résumé
Vaccination in pregnancy guards against infection. Maternal antibodies, however, can inhibit antibody production in neonates. We sought to determine the effects of maternal vaccination on neonatal immune response to a SARS-CoV-2 mRNA vaccine. We hypothesized that mRNA-lipid nanoparticles (LNP) vaccination allows for a de novo neonatal antibody response even in the presence of vertically transmitted maternal antibodies. Female mice were vaccinated with SARS-CoV-2 spike receptor binding domain (RBD) mRNA-LNPs. Mice were then bred, and 21-day-old pups were inoculated with the same mRNA-LNPs. Spike-specific IgG ELISAs were performed using mouse serum. A SARS-CoV-2 spike protein peptide library to perform peptide ELISAs characterized high affinity binding domains within the spike protein. Results were analyzed with one-way ANOVAs with Tukey's multiple comparisons tests. Compared to pups of unvaccinated dams, there were high levels of spike-specific IgG detected in the pups of vaccinated dams at 3 weeks of life (p < 0.0001). After neonatal vaccination, pups of unvaccinated dams had higher spike-specific serum IgG than pups of vaccinated dams at 12 weeks of life (p < 0.001). Antibody specificity to peptide moieties within spike RBD were similar when comparing a vaccinated dam to her pup at Week 3 of life, with different binding affinities observed in the pups by Week 15 of life. Pre-existing maternal antibodies may partially blunt the initial neonatal antibody response to mRNA-LNPs vaccination. This vaccine strategy, however, does not prohibit the subsequent development of a broad range of RBD antibody specificities that may be protective.
Substances chimiques
Spike Glycoprotein, Coronavirus
0
Antibodies, Viral
0
COVID-19 Vaccines
0
Immunoglobulin G
0
spike protein, SARS-CoV-2
0
Lipid Nanoparticles
0
RNA, Messenger
0
mRNA Vaccines
0
Liposomes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e70001Subventions
Organisme : NIH HHS
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30GM118228-05
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20RR021905
Pays : United States
Informations de copyright
© 2024 The Author(s). American Journal of Reproductive Immunology published by John Wiley & Sons Ltd.
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