The Involvement of GABA in the Modulation of the Rhythm of Electrical Activity in the Small Intestine during Food Deprivation.
GABA
food deprivation
migrating myoelectric complex (MMC)
rats
Journal
Bulletin of experimental biology and medicine
ISSN: 1573-8221
Titre abrégé: Bull Exp Biol Med
Pays: United States
ID NLM: 0372557
Informations de publication
Date de publication:
22 Oct 2024
22 Oct 2024
Historique:
received:
27
02
2024
medline:
22
10
2024
pubmed:
22
10
2024
entrez:
22
10
2024
Statut:
aheadofprint
Résumé
In experiments on male Wistar rats, the stages of adaptive changes in the rhythm of periodic electrical activity in the small intestine during food deprivation were identified and the effect of GABA on changes of the rhythm under these conditions was assessed. It was found that on days 1-3 of food deprivation, the migrating myoelectric complex (MMC) in the small intestine is preserved, but the cycle becomes rarer. On days 4-6, MMC disappears, irregular and regular activity with no periods of quiescence is recorded. On days 7-9, predominantly irregular activity of the small intestine with short quiescence periods is observed. Enteral administration of GABA at different stages of food deprivation modulates electrical activity and preserves small intestinal MMC.
Identifiants
pubmed: 39436573
doi: 10.1007/s10517-024-06253-2
pii: 10.1007/s10517-024-06253-2
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. Springer Science+Business Media, LLC, part of Springer Nature.
Références
Korot’ko GF. Ross. Zh. Polyfunctionality of periodic activity of the digestive system (Century after discovery). Gastroenterol. Gepatol. Koloproktol. 2013;23(6):4-10. Russian.
Amer A, Breu J, McDermott J, Wurtman RJ, Maher TJ. 5-Hydroxy-L-tryptophan suppresses food intake in food-deprived and stressed rats. Pharmacol. Biochem. Behav. 2004;77(1):137-143. https://doi.org/10.1016/j.pbb.2003.10.011
doi: 10.1016/j.pbb.2003.10.011
pubmed: 14724051
Ko KI, Root CM, Lindsay SA, Zaninovich OA, Shepherd AK, Wasserman SA, Kim SM, Wang JW. Starvation promotes concerted modulation of appetitive olfactory behavior via parallel neuromodulatory circuits. Elife. 2015;4:e08298. https://doi.org/10.7554/eLife.08298 .
doi: 10.7554/eLife.08298
pubmed: 26208339
pmcid: 4531282
Karami KJ, Coppola J, Krishnamurthy K, Llanos DJ, Mukherjee A, Venkatachalam KV. Effect of food deprivation and hormones of glucose homeostasis on the acetyl CoA carboxylase activity in mouse brain: a potential role of acc in the regulation of energy balance. Nutr. Metab. (Lond). 2006;3:15. https://doi.org/10.1186/1743-7075-3-15
Malomouzh A, Ilyin V, Nikolsky E. Components of the GABAergic signaling in the peripheral cholinergic synapses of vertebrates: a review. Amino Acids. 2019;51(8):1093-1102. https://doi.org/10.1007/s00726-019-02754-x
doi: 10.1007/s00726-019-02754-x
pubmed: 31236726
Bayer S, Crenner F, Aunis D, Angel F. Effects of GABA on circular smooth muscle spontaneous activities of rat distal colon. Life Sci. 2002;71(8):911-925. https://doi.org/10.1016/s0024-3205(02)01771-x
doi: 10.1016/s0024-3205(02)01771-x
pubmed: 12084388
Auteri M, Zizzo MG, Mastropaolo M, Serio R. Opposite role played by GABAA and GABAB receptors in the modulation of peristaltic activity in mouse distal colon. Eur. J. Pharmacol. 2014;731:93-99. https://doi.org/10.1016/j.ejphar.2014.03.003
doi: 10.1016/j.ejphar.2014.03.003
pubmed: 24642362
Zizzo MG, Mulè F, Serio R. Functional evidence for GABA as modulator of the contractility of the longitudinal muscle in mouse duodenum: role of GABA(A) and GABA(C) receptors. Neuropharmacology. 2007;52(8):1685-1690. https://doi.org/10.1016/j.neuropharm.2007.03.016
doi: 10.1016/j.neuropharm.2007.03.016
pubmed: 17517423
Zizzo MG, Cicio A, Raimondo S, Alessandro R, Serio R. Age-related differences of γ-aminobutyric acid (GABA)ergic transmission in human colonic smooth muscle. Neurogastroenterol. Motil. 2022;34(3):e14248. https://doi.org/10.1111/nmo.14248
doi: 10.1111/nmo.14248
pubmed: 34432349
Wood JD. Autonomic brain in the gut. Integr. Physiol. 2020;1(1):5-10. https://doi.org/10.33910/2687-1270-2020-1-1-5-10
Ohnyanskaya LG, Vishnyakova IN. Ivan Petrovich Razenkov, 1888-1954. Moscow, 2004. Russian.
Krantis A. GABA in the mammalian enteric nervous system. News Physiol. Sci. 2000;15:284-290. https://doi.org/10.1152/physiologyonline.2000.15.6.284
doi: 10.1152/physiologyonline.2000.15.6.284
pubmed: 11390928
Beloborodaya MV, Rutkevich SA, Chumak AG. Realization of the influence of the vagus nerve on intestinal motility under the influence of inhibitory amino acids. Trudy Belorusskogo Univ. Ser. Fiziol. Biokhim. Molekular. Osnovy Funktsionir. Biosistem. 2011;6(1):33-38. Russian.
Gurman YuV, Tropskaya NS, Popova TS. The role of cholinergic mechanisms in the effects of GABA on the small bowel electrical activity. Biomeditsina. 2021;17(S3):147-150. Russian. https://doi.org/10.33647/2713-0428-17-3E-147-150