Subclinical cardiac damage monitoring in breast cancer patients treated with an anthracycline-based chemotherapy receiving left-sided breast radiation therapy: subgroup analysis from a phase 3 trial.

Anthracycline-based chemotherapy Breast cancer Cardioprotective therapy Left-sided breast radiotherapy Subclinical cardiac damage

Journal

La Radiologia medica
ISSN: 1826-6983
Titre abrégé: Radiol Med
Pays: Italy
ID NLM: 0177625

Informations de publication

Date de publication:
22 Oct 2024
Historique:
received: 29 07 2024
accepted: 05 10 2024
medline: 22 10 2024
pubmed: 22 10 2024
entrez: 22 10 2024
Statut: aheadofprint

Résumé

This study, derived from the phase 3 SAFE trial (ClinicalTrials.gov identifier: NCT2236806), explores subclinical cardiac damage in breast cancer patients receiving anthracycline-based chemotherapy and left-sided breast radiation therapy (RT). Eligible patients were randomized to a cardioprotective pharmacological therapy (bisoprolol, ramipril, or both) or placebo, with cardiac surveillance at multiple time-point using standard and 3-dimensional echocardiography. Dosimetric parameters were analysed, including mean heart dose (MHD) and various metrics for heart substructures, employing advanced contouring techniques and auto-contouring software. In the analysis of left-sided breast RT patients, the study encompassed 39 out of 46 irradiated individuals, focusing on GLS and 3D-LVEF outcomes with ≥ 10% worsening, defined as subclinical heart damage. Distinct RT schedules were used, with placebo exhibiting the highest ≥ 10% worsening (36.4%). In terms of treatment arms, bisoprolol exhibited 11.1% worsening, while ramipril 16.7% and bisoprolol + ramipril 25%. For patients with no subclinical damage, the mean MHD was 1.5 Gy; for patients with subclinical heart damage, the mean MHD was 1.6 Gy (p = 0.94). Dosimetric parameters related to heart and heart substructures (left anterior descending artery, right and left atrium, right and left ventricle) showed no statistically significant differences between patients with and without subclinical damage. Our results emphasize the crucial role of cardioprotective measures in mitigating adverse effects, highlighting RT as having negligible influence on cardiac performance. An extended follow-up assessment of the whole series is warranted to determine whether a subclinical effect could significantly influence clinical outcomes and cardiac events.

Identifiants

pubmed: 39436588
doi: 10.1007/s11547-024-01897-6
pii: 10.1007/s11547-024-01897-6
doi:

Banques de données

ClinicalTrials.gov
['NCT02236806']

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. Italian Society of Medical Radiology.

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Auteurs

Livia Marrazzo (L)

Department of Experimental and Clinical Biomedical Sciences "M. Serio", University of Florence, Florence, Italy.
Medical Physics Unit, Oncology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Icro Meattini (I)

Department of Experimental and Clinical Biomedical Sciences "M. Serio", University of Florence, Florence, Italy. icro.meattini@unifi.it.
Radiation Oncology and Breast Unit, Oncology Department, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 50, 50134, Florence, Italy. icro.meattini@unifi.it.

Carlotta Becherini (C)

Radiation Oncology and Breast Unit, Oncology Department, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 50, 50134, Florence, Italy.

Viola Salvestrini (V)

Radiation Oncology and Breast Unit, Oncology Department, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 50, 50134, Florence, Italy.

Luca Visani (L)

Radiation Oncology and Breast Unit, Oncology Department, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 50, 50134, Florence, Italy.

Giuseppe Barletta (G)

CardioThoracic and Vascular Department, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Calogero Saieva (C)

Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for Cancer Research Prevention and Clinical Network (ISPRO), Florence, Italy.

Maria Riccarda Del Bene (MR)

CardioThoracic and Vascular Department, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Giuseppe Pilato (G)

CardioThoracic and Vascular Department, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Isacco Desideri (I)

Department of Experimental and Clinical Biomedical Sciences "M. Serio", University of Florence, Florence, Italy.
Radiation Oncology and Breast Unit, Oncology Department, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 50, 50134, Florence, Italy.

Chiara Arilli (C)

Medical Physics Unit, Oncology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Lisa Paoletti (L)

Breast Unit, Oncology Department, Azienda USL Toscana Centro, Florence, Italy.

Serenella Russo (S)

Breast Unit, Oncology Department, Azienda USL Toscana Centro, Florence, Italy.

Silvia Scoccianti (S)

Breast Unit, Oncology Department, Azienda USL Toscana Centro, Florence, Italy.

Francesca Martella (F)

Breast Unit, Oncology Department, Azienda USL Toscana Centro, Florence, Italy.

Giulio Francolini (G)

Radiation Oncology and Breast Unit, Oncology Department, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 50, 50134, Florence, Italy.

Gabriele Simontacchi (G)

Radiation Oncology and Breast Unit, Oncology Department, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 50, 50134, Florence, Italy.

Jacopo Nori Cucchiari (J)

Radiation Oncology and Breast Unit, Oncology Department, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 50, 50134, Florence, Italy.

Roberto Pellegrini (R)

Elekta AB, Stockholm, Sweden.

Lorenzo Livi (L)

Department of Experimental and Clinical Biomedical Sciences "M. Serio", University of Florence, Florence, Italy.
Radiation Oncology and Breast Unit, Oncology Department, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni 50, 50134, Florence, Italy.

Stefania Pallotta (S)

Department of Experimental and Clinical Biomedical Sciences "M. Serio", University of Florence, Florence, Italy.
Medical Physics Unit, Oncology Department, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Classifications MeSH