A small-molecule carrier for the intracellular delivery of a membrane-impermeable protein with retained bioactivity.
boron clusters
chaotropic effect
cytochrome C
lipid bilayer permeation
protein delivery
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
29 Oct 2024
29 Oct 2024
Historique:
medline:
22
10
2024
pubmed:
22
10
2024
entrez:
22
10
2024
Statut:
ppublish
Résumé
Intracellular protein delivery has the potential to revolutionize cell-biological research and medicinal therapy, with broad applications in bioimaging, disease treatment, and genome editing. Herein, we demonstrate successful delivery of a functional protein, cytochrome c (CYC), by using a boron cluster anion as molecular carrier of the superchaotropic anion type (B
Identifiants
pubmed: 39436658
doi: 10.1073/pnas.2407515121
doi:
Substances chimiques
Cytochromes c
9007-43-6
Lipid Bilayers
0
Drug Carriers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2407515121Subventions
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 42061134020
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 22177133
Organisme : MOST | National Natural Science Foundation of China (NSFC)
ID : 22278438
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : NA 686/14
Organisme : Deutsche Forschungsgemeinschaft (DFG)
ID : NA 686/15
Déclaration de conflit d'intérêts
Competing interests statement:A.B.-B. and W.M.N. are co-inventors on a related patent (WO 2021/259668 A1).