Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice.

Animals Ion Channels / metabolism Ghrelin / metabolism Mice Liver / metabolism Lipid Metabolism Mice, Knockout Mechanotransduction, Cellular Fatty Liver / metabolism Homeostasis Diet, High-Fat / adverse effects Mice, Inbred C57BL Male

Journal

Science signaling
ISSN: 1937-9145
Titre abrégé: Sci Signal
Pays: United States
ID NLM: 101465400

Informations de publication

Date de publication:
22 Oct 2024
Historique:
medline: 22 10 2024
pubmed: 22 10 2024
entrez: 22 10 2024
Statut: ppublish

Résumé

Ghrelin is an orexigenic peptide released by gastric ghrelin cells that contributes to obesity and hepatic steatosis. The mechanosensitive ion channel Piezo1 in gastric ghrelin cells inhibits the synthesis and secretion of ghrelin in response to gastric mechanical stretch. We sought to modulate hepatic lipid metabolism by manipulating Piezo1 in gastric ghrelin cells. Mice with a ghrelin cell-specific deficiency of

Identifiants

DOI: 10.1126/scisignal.adq9463 PMID: 39436995
pubmed: 39436995
doi: 10.1126/scisignal.adq9463
doi:

Substances chimiques

Piezo1 protein, mouse 0
Ion Channels 0
Ghrelin 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadq9463

Auteurs

Jinshan Zhang (J)

Department of Physiology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510632, China.
Department of Metabolic and Bariatric Surgery, First Affiliated Hospital of Jinan University, 613 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510630, China.
ORCID: 0009-0006-2201-9476

Yawen Zhao (Y)

Department of Physiology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510632, China.

Shaohong Wu (S)

Department of Physiology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510632, China.

Mengxue Han (M)

Department of Physiology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510632, China.

Luyang Gao (L)

Department of Physiology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510632, China.

Ke Yang (K)

Department of Physiology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510632, China.

Hui Chen (H)

Biotherapy Center; Cell-gene Therapy Translational Medicine Research Center, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China.

Cunchuan Wang (C)

Department of Metabolic and Bariatric Surgery, First Affiliated Hospital of Jinan University, 613 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510630, China.
ORCID: 0000-0003-2576-7462

Geyang Xu (G)

Department of Physiology, School of Medicine, Jinan University, 601 Huangpu Avenue West, Tianhe District, Guangzhou, Guangdong 510632, China.
Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, 510632 Guangzhou, Guangdong, China.
ORCID: 0000-0002-5542-1350

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mechanosensing by Piezo1 in gastric ghrelin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Mechanosensing by Piezo1 in gastric ghrelin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Ghréline › Mechanosensing by Piezo1 in gastric ghrelin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mechanosensing by Piezo1 in gastric ghrelin...
questionsmedicales.fr › Système digestif › Foie › Mechanosensing by Piezo1 in gastric ghrelin...
questionsmedicales.fr › Métabolisme › Métabolisme lipidique › Mechanosensing by Piezo1 in gastric ghrelin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Mechanosensing by Piezo1 in gastric ghrelin...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Mécanotransduction cellulaire › Mechanosensing by Piezo1 in gastric ghrelin...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Stéatose hépatique › Mechanosensing by Piezo1 in gastric ghrelin...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Mechanosensing by Piezo1 in gastric ghrelin...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Alimentation riche en graisse › Mechanosensing by Piezo1 in gastric ghrelin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Mechanosensing by Piezo1 in gastric ghrelin...