Humans without a sense of smell breathe differently.

Humans Adult Smell / physiology Male Female Respiration Anosmia / physiopathology Sleep / physiology Middle Aged Odorants Young Adult Wearable Electronic Devices Nose / physiopathology Case-Control Studies Olfaction Disorders / congenital

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
22 Oct 2024
Historique:
received: 10 07 2023
accepted: 18 09 2024
medline: 23 10 2024
pubmed: 23 10 2024
entrez: 22 10 2024
Statut: epublish

Résumé

Olfaction may play a restricted role in human behavior, yet paradoxically, its absence in anosmia is associated with diverse deleterious outcomes, culminating in reduced life expectancy. The mammalian nose serves two purposes: olfaction and breathing. Because respiratory patterns are impacted by odors, we hypothesized that nasal respiratory airflow may be altered in anosmia. We apply a wearable device that precisely logs nasal airflow for 24-hour-long sessions in participants with isolated congenital anosmia and controls. We observe significantly altered patterns of respiratory nasal airflow in anosmia in wake and in sleep. These differences allow classification of anosmia at 83% accuracy using the respiratory trace alone. Patterns of respiratory airflow have pronounced impact on health, emotion and cognition. We therefore suggest that a portion of the deleterious outcomes associated with anosmia may be attributed to altered patterns of respiratory nasal airflow rather than a direct result of lost odor perception per se.

Identifiants

DOI: 10.1038/s41467-024-52650-6 PMID: 39438441
pubmed: 39438441
doi: 10.1038/s41467-024-52650-6
pii: 10.1038/s41467-024-52650-6
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8809

Subventions

Organisme : Israel Science Foundation (ISF)
ID : 2751/23
Organisme : Minerva Foundation (Minerva Stiftung)
ID : 714146

Informations de copyright

© 2024. The Author(s).

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Auteurs

Lior Gorodisky (L)

The Azrieli National Institute for Human Brain Imaging and Research, Weizmann Institute of Science, Rehovot, Israel. lior.gorodisky@weizmann.ac.il.
Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel. lior.gorodisky@weizmann.ac.il.
ORCID: 0000-0001-7972-1123

Danielle Honigstein (D)

The Azrieli National Institute for Human Brain Imaging and Research, Weizmann Institute of Science, Rehovot, Israel.
Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.

Aharon Weissbrod (A)

The Azrieli National Institute for Human Brain Imaging and Research, Weizmann Institute of Science, Rehovot, Israel.
Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.

Reut Weissgross (R)

The Azrieli National Institute for Human Brain Imaging and Research, Weizmann Institute of Science, Rehovot, Israel.
Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.

Timna Soroka (T)

The Azrieli National Institute for Human Brain Imaging and Research, Weizmann Institute of Science, Rehovot, Israel.
Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.

Sagit Shushan (S)

The Azrieli National Institute for Human Brain Imaging and Research, Weizmann Institute of Science, Rehovot, Israel.
Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel.
The Institute of Nose and Sinus Therapy and Clinical Investigations, The Edith Wolfson Medical Center, Holon, Israel.
Department of Otolaryngology-Head & Neck Surgery, The Edith Wolfson Medical Center, Holon, Israel.
Faculty of Medical & Health Sciences, Tel-Aviv University, Tel Aviv, Israel.

Noam Sobel (N)

The Azrieli National Institute for Human Brain Imaging and Research, Weizmann Institute of Science, Rehovot, Israel. noam.sobel@weizmann.ac.il.
Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel. noam.sobel@weizmann.ac.il.
ORCID: 0000-0002-3232-9391

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Humans without a sense of smell breathe differently.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Humans without a sense of smell breathe differently.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Odorat › Humans without a sense of smell breathe differently.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Respiration › Humans without a sense of smell breathe differently.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Troubles sensitifs › Troubles de l'olfaction › Anosmie › Humans without a sense of smell breathe differently.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sommeil › Humans without a sense of smell breathe differently.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Humans without a sense of smell breathe differently.
questionsmedicales.fr › Environnement et santé publique › Environnement › Odorisants › Humans without a sense of smell breathe differently.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Humans without a sense of smell breathe differently.
questionsmedicales.fr › Équipement et fournitures › Équipement et fournitures électriques › Dispositifs électroniques portables › Humans without a sense of smell breathe differently.
questionsmedicales.fr › Organes des sens › Nez › Humans without a sense of smell breathe differently.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Humans without a sense of smell breathe differently.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Troubles sensitifs › Troubles de l'olfaction › Humans without a sense of smell breathe differently.