Biochemical and biological studies of irradiated and non-irradiated extracts of Solanum aculeastrum Dunal fruit.
Solanum
/ chemistry
Plant Extracts
/ pharmacology
Humans
Fruit
/ chemistry
Microbial Sensitivity Tests
Anti-Bacterial Agents
/ pharmacology
Gamma Rays
Molecular Docking Simulation
Aminoacyltransferases
/ antagonists & inhibitors
Cell Line, Tumor
Flavonoids
/ pharmacology
Bacterial Proteins
/ metabolism
Phenols
/ pharmacology
HCT116 Cells
Cysteine Endopeptidases
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
22 10 2024
22 10 2024
Historique:
received:
28
01
2024
accepted:
18
09
2024
medline:
23
10
2024
pubmed:
23
10
2024
entrez:
22
10
2024
Statut:
epublish
Résumé
This study explores the impact of γ-irradiation on ethanolic extracts of Solanum aculeastrum Dunal. The anti-cancer and antimicrobial properties were investigated. The obtained results revealed that total phenol (TP) and total flavonoid (TF) of total ethanol extract (100%) (FTE) were higher than 70% ethanol extract (SE), and these contents increased after gamma radiation with 5 kGy. The results of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the Solanum aculeastrum extracts suggested that FTE and 5 kGy-irradiated FTE can be used to control and prevent skin infections caused by MRSA and endocarditis, urinary tract infections, and prostatitis caused by Enterococcus faecalis. The FTE sample irradiated at 5 kGy showed cytotoxicity for A431 and Hct-116 cell lines similar to the control sample and higher than the toxicity revealed by the samples irradiated at 10 kGy. In normal cells (Bj-1), the toxicity was decreased after irradiation (IC50 = 31 μg/ml) compared to the non-irradiated extract (IC
Identifiants
pubmed: 39438506
doi: 10.1038/s41598-024-73531-4
pii: 10.1038/s41598-024-73531-4
doi:
Substances chimiques
Plant Extracts
0
Anti-Bacterial Agents
0
sortase A
EC 2.3.2.-
Aminoacyltransferases
EC 2.3.2.-
Flavonoids
0
Bacterial Proteins
0
Phenols
0
Cysteine Endopeptidases
EC 3.4.22.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
24829Informations de copyright
© 2024. The Author(s).
Références
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