Four New Tirucallane Triterpenoids from the Leaves of Ailanthus triphysa with Anti-inflammatory Activities.

Ailanthus triphysa, Simaroubaceae, tirucallane triterpene, ailantriphysa, anti-inflammatory activity

Journal

Chemistry & biodiversity
ISSN: 1612-1880
Titre abrégé: Chem Biodivers
Pays: Switzerland
ID NLM: 101197449

Informations de publication

Date de publication:
23 Oct 2024
Historique:
revised: 22 10 2024
received: 10 10 2024
accepted: 23 10 2024
medline: 23 10 2024
pubmed: 23 10 2024
entrez: 23 10 2024
Statut: aheadofprint

Résumé

Ten tirucallane triterpenes (1-10) including four undescribed compounds, ailantriphysas A-D (1-4), were isolated from the leaves of Ailanthus triphysa (Dennst.) Alston. Their structures were elucidated by using IR, HR-ESI-MS, 1D- and 2D-NMR spectra. Compound 1 exhibited nitric oxide inhibitory activity with a IC50 value of 8.1 ± µM. Additionally, compound 1 also displayed significant inhibitory effects on the secretion of IL-6 and TNF-α at tested concentrations of 4, 8, and 16 µM.

Identifiants

DOI: 10.1002/cbdv.202402584 PMID: 39440571
pubmed: 39440571
doi: 10.1002/cbdv.202402584
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e202402584

Informations de copyright

© 2024 Wiley‐VCH GmbH.

Auteurs

Nguyen Duc Duy (ND)

Vietnam Academy of Science and Technology, Center for High Technology Research and Development, Hoang Quoc Viet, Hanoi, 10072, Hanoi, VIET NAM.

Duong Thi Dung (DT)

Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, Hoang Quoc Viet, Hanoi, 10072, Hanoi, VIET NAM.

Do Thi Trang (DT)

Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam, Hanoi, 84, Hanoi, VIET NAM.

Ngo Anh Bang (NA)

Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, Hoang Quoc Viet, Hanoi, Hanoi, VIET NAM.

Pham Hai Yen (PH)

Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, Hoang Quoc Viet, Hanoi, 10072, Hanoi, VIET NAM.

Nguyen Xuan Nhiem (NX)

Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, 18 Hoang Quoc Viet, Hà Nội, 10072, Hà Nội, VIET NAM.

Nguyen Thi Cuc (NT)

Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, 18 Hoang Quoc Viet, Hanoi, 10072, Hanoi, VIET NAM.

Phan Thi Thanh Huong (PTT)

Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, Hoang Quoc Viet, Hanoi, 10072, Hanoi, VIET NAM.

Nguyen Viet Dung (NV)

Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, Hoang Quoc Viet, Hanoi, 10072, Hanoi, VIET NAM.

Nguyen Huy Hoang (NH)

Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, Hoang Quoc Viet, Hanoi, 10072, Hanoi, VIET NAM.

Duong Thi Hai Yen (DTH)

Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, Hoang Quoc Viet, Hanoi, 10072, Hanoi, VIET NAM.

Nguyen The Cuong (NT)

Vietnam Academy of Science and Technology, Institute of Ecology and Biological Resources, 18 Hoang QUoc Viet, Hanoi, 10072, Hanoi, VIET NAM.

Nguyen Thi Kim Thuy (NTK)

Vietnam Academy of Science and Technology, Center for High Technology Research and Development, Hoang Quoc Viet, Hanoi, 10072, Hanoi, VIET NAM.

Bui Huu Huu Tai (BH)

Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, 18 Hoang Quoc Viet, Hanoi, 10072, Hanoi, VIET NAM.

Phan Van Kiem (PV)

Vietnam Academy of Science and Technology, Department of Structural Research, 18 Hoang Quoc Viet, 10000, Hanoi, VIET NAM.

Classifications MeSH