Improvement of salivary biomarkers vitronectin and fetuin-A levels in periodontitis patients with coronary artery disease post scaling and root planing.
biomarkers
cardiovascular diseases
glycoproteins
molecular biology
periodontal medicine
periodontitis
Journal
Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
ISSN: 1754-4505
Titre abrégé: Spec Care Dentist
Pays: United States
ID NLM: 8103755
Informations de publication
Date de publication:
23 Oct 2024
23 Oct 2024
Historique:
revised:
05
09
2024
received:
10
06
2024
accepted:
02
10
2024
medline:
23
10
2024
pubmed:
23
10
2024
entrez:
23
10
2024
Statut:
aheadofprint
Résumé
Two biomarkers that are gaining attention for their roles in the progression of both periodontal and cardiovascular diseases are vitronectin and fetuin-A. This study evaluated vitronectin and fetuin-A expression in saliva samples of periodontitis (P) patients with and without coronary artery disease (CAD) after scaling and root planing (SRP). Sixty patients were divided into three groups: PH + SH (periodontally and systemically healthy), P (stage II/III grade B periodontitis), and P + CAD (periodontitis with CAD). Demographic, periodontal, and cardiac parameters were recorded. Unstimulated saliva samples were collected at baseline (day 0) and after SRP. On day 90, periodontal parameters and vitronectin/fetuin-A expression were reassessed. P + CAD patients had higher age, weight, BMI, and lower income (p < .001, .025, .002, < .001, respectively), along with elevated plaque index, bleeding on probing, probing pocket depth, and reduced clinical attachment levels (p < .001). Vitronectin was elevated, while fetuin-A was lower in P + CAD, but both improved post-SRP (p < .001). Enhanced vitronectin and fetuin-A levels post-SRP indicate their potential as biomarkers and therapeutic targets for both periodontal and CAD.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024 Special Care Dentistry Association and Wiley Periodicals LLC.
Références
Könönen E, Gursoy M, Gursoy UK. Periodontitis: a multifaceted disease of tooth‐supporting tissues. J Clin Med. 2019;8(8):1135
Lasserre JF, Brecx MC, Toma S. Oral microbes, biofilms and their role in periodontal and peri‐implant diseases. Materials. 2018;11(10):1802
Zardawi F, Gul S, Abdulkareem A, Sha A, Yates J. Association between periodontal disease and atherosclerotic cardiovascular diseases: revisited. Front Cardiovasc Med. 2021;7:625579.
Nazir MA. Prevalence of periodontal disease, its association with systemic diseases and prevention. Int J Health Sci. 2017;11(2):72.
Korte DL, Kinney J. Personalized medicine: an update of salivary biomarkers for periodontal diseases. Periodontol 2000. 2016;70(1):26‐37.
Hayman EG, Pierschbacher MD, Ohgren Y, Ruoslahti E. Serum spreading factor vitronectin is present at the cell surface and in tissues. Proc Natl Acad Sci. 1983;80(13):4003‐4007.
Schäfer C, Heiss A, Schwarz A, et al. The serum protein α 2–Heremans‐Schmid glycoprotein/fetuin‐A is a systemically acting inhibitor of ectopic calcification. J Clin Investig. 2003;112(3):357‐366.
World Medical Association. World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. Jama. 2013;310(20):2191‐2194.
Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: framework and proposal of a new classification and case definition. J Periodontol. 2018;89:S159‐S172
Arnett DK, Blumenthal RS, Albert MA, et al. 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: a report of the American College of Cardiology/American Heart Association task force on clinical practice guidelines. Circulation, 2019;140(11):e596‐e646.
Silness J, Loe H. Periodontal disease in pregnancy. ii. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand. 1964;22:121‐135.
Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J. 1975;25(4):229‐235
Bradley RD, Oberg EB. Are additional lipid measures useful? Integr Med. 2008;7(6):18‐23
Members WG, Benjamin EJ, Blaha MJ, et al. Heart disease and stroke statistics—2017 update: a report from the American Heart Association. Circulation. 2017;135(10):e146‐e603.
Yoshizawa JM, Schafer CA, Schafer JJ, Farrell JJ, Paster BJ, Wong DT. Salivary biomarkers: toward future clinical and diagnostic utilities. Clin Microbiol Rev. 2013;26(4):781‐791.
Pal D, Nasim F, Chakrabarty H, Chakraborty A. Non surgical periodontal therapy: an evidence‐based perspective. J dent Panacea. 2021;3(2):48‐51
Mahendra J, Srinivasan S, Kanakamedala A, et al. Expression of trefoil factor 2 and 3 and adrenomedullin in chronic periodontitis subjects with coronary heart disease. J Periodontol. 2023;94(5):694‐703.
Rodgers JL, Jones J, Bolleddu SI, et al. Cardiovascular risks associated with gender and aging. J Cardiovasc Dev Dis. 2019;6(2):19.
Jia R, Zhang Y, Wang Z, Hu B, Wang Z, Qiao H. Association between lipid metabolism and periodontitis in obese patients: a cross‐sectional study. BMC Endocr Disord. 2023;23(1):119.
Limpijankit T, Vathesatogkit P, Matchariyakul D, et al. Causal relationship of excess body weight on cardiovascular events through risk factors. Sci Rep. 2022;12(1):5269.
Schindler TH, Cardenas J, Prior JO, et al. Relationship between increasing body weight, insulin resistance, inflammation, adipocytokine leptin, and coronary circulatory function. J Am Coll Cardiol. 2006;47(6):1188‐1195.
Byun SH, Lee S, Kang SH, Choi HG, Hong SJ. Cross‐sectional analysis of the association between periodontitis and cardiovascular disease using the Korean genome and epidemiology study data. Int J Environ Res Public Health. 2020;17(14):5237.
Arsenault BJ, Kamstrup PR. Lipoprotein (a) and cardiovascular and valvular diseases: a genetic epidemiological perspective. Atherosclerosis. 2022;349:7‐16.
Fentoglu O, Kirzioglu FY, Ozdem M, Koçak H, Sutçu R, Sert T. Pro‐inflammatory cytokine levels in hyperlipidemic patients with periodontitis after periodontal treatment. Oral Dis. 2012;18:299–306.
Cicmil S, Cicmil A, Pavlic V, et al. Periodontal disease in young adults as a risk factor for subclinical atherosclerosis: a clinical, biochemical and immunological study. J Clin Med. 2023;12(6):2197.
Al‐Isa M, Alotibi M, Alhashemi H, Althobiani F, Atia A, Baz S. Effect of non‐surgical periodontal therapy on the fibrinogen levels in chronic periodontitis patients. Saudi Dent J. 2019;31(2):188‐193
Ekmekci H, Ekmekci OB, Sonmez H, Ozturk Z, Domanic N, Kokoglu E. Evaluation of fibronectin, vitronectin, and leptin levels in coronary artery disease: impacts on thrombosis and thrombolysis. Clin Appl Thromb/Hemost. 2005;11(1):63‐70.
Bhakdi S, Käflein R, Halstensen TS, Hugo F, Preissner KT, Mollnes TE. Complement S‐protein (vitronectin) is associated with cytolytic membrane‐bound C5b‐9 complexes. Clin Exp Immunol. 1988;74(3):459.
Doğan GE, Demir T, Laloğlu E, et al. Patients with dental calculus have increased saliva and gingival crevicular fluid fetuin‐A levels but no association with fetuin‐A polymorphisms. Braz Oral Res. 2016;30(2):121‐126.
Furugen R, Kawasaki K, Kitamura M, Maeda T, Saito T, Hayashida H. Association of low fetuin‐A levels with periodontitis in community‐dwelling adults. J Oral Sci. 2020;62(1):67‐69.
Nair S, Nisha KJ. Evaluation of the effect of scaling and root planing on salivary and serum fetuin‐A levels in patients with Stages II and III periodontitis. J Periodontol. 2022;93(2):179‐188.