Human transforming growth factor β type I receptor in complex with kinase inhibitor SB505124.
TGF-β type I receptor
inhibition
intracellular domain
osteoblast differentiation
prostate cancer
Journal
Acta crystallographica. Section F, Structural biology communications
ISSN: 2053-230X
Titre abrégé: Acta Crystallogr F Struct Biol Commun
Pays: United States
ID NLM: 101620319
Informations de publication
Date de publication:
01 Nov 2024
01 Nov 2024
Historique:
medline:
23
10
2024
pubmed:
23
10
2024
entrez:
23
10
2024
Statut:
aheadofprint
Résumé
The crystal structure of the intracellular domain of transforming growth factor β type I receptor (TβR1) in complex with the competitive inhibitor SB505124 is presented. The study provides insights into the structure and function of TβR1 in complex with SB505124, and as such offers molecular-level understanding of the inhibition of this critical signalling pathway. The potential of SB505124 as an avenue for therapy in cancer treatment is discussed on basis of the results.
Identifiants
pubmed: 39441620
pii: S2053230X24010094
doi: 10.1107/S2053230X24010094
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Vetenskapsrådet
ID : 2021-04513_VR
Organisme : Vetenskapsrådet
ID : 2023-02370_VR
Organisme : Cancerfonden
ID : 23 2902 Pj 01H
Organisme : Umeå Universitet
ID : FS 506-21
Informations de copyright
open access.