Multiomic and clinical analysis of multiply recurrent meningiomas reveals risk factors, underlying biology, and insights into evolution.

Humans Meningioma / genetics Male Female DNA Methylation Neoplasm Recurrence, Local / genetics Middle Aged Risk Factors Meningeal Neoplasms / genetics DNA Copy Number Variations Aged Adult Gene Expression Regulation, Neoplastic Epigenesis, Genetic

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
25 Oct 2024
Historique:
medline: 24 10 2024
pubmed: 23 10 2024
entrez: 23 10 2024
Statut: ppublish

Résumé

An important subset of meningiomas behaves aggressively and is characterized by multiple recurrences. We identify clinical, genetic, and epigenetic predictors of multiply recurrent meningiomas (MRMs) and evaluate the evolution of these meningiomas in patient-matched samples. On multivariable binomial logistic regression, MRMs were significantly associated with male sex (

Identifiants

DOI: 10.1126/sciadv.adn4419 PMID: 39441930
pubmed: 39441930
doi: 10.1126/sciadv.adn4419
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadn4419

Auteurs

Sangami Pugazenthi (S)

Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.
ORCID: 0000-0002-5179-5232

Bhuvic Patel (B)

Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.
The Brain Tumor Center, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
ORCID: 0000-0001-8062-7310

Collin W English (CW)

Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
ORCID: 0000-0003-3730-2793

William A Leidig (WA)

Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.

Kyle P McGeehan (KP)

Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO, USA.
ORCID: 0000-0001-5614-217X

Colin R McCornack (CR)

Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO, USA.
ORCID: 0000-0002-7781-1456

Shinghei Mok (S)

Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.
ORCID: 0009-0000-2105-8883

Markus Anzaldua-Campos (M)

Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.

Shervin Hosseingholi Nouri (SH)

Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.
ORCID: 0009-0002-9454-6700

Kaleigh Roberts (K)

Department of Neuropathology, Washington University School of Medicine, St. Louis, MO, USA.
ORCID: 0000-0001-6483-9153

Ajay Chatrath (A)

Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.
ORCID: 0000-0003-1309-9612

A Khan (A)

Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.

Ron Gadot (R)

Department of Neurosurgery, Baylor College of Medicine, Houston, TX, USA.

Hiroko Yano (H)

Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.
The Brain Tumor Center, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.

Tiemo J Klisch (TJ)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.
ORCID: 0000-0001-8182-384X

Akdes S Harmanci (AS)

The Brain Tumor Center, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
Center for Cancer Neuroscience, Baylor College of Medicine, Houston, TX, USA.
ORCID: 0000-0001-6374-9041

Akash J Patel (AJ)

The Brain Tumor Center, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.
Center for Cancer Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA.
ORCID: 0000-0002-1280-2989

Albert H Kim (AH)

Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO, USA.
The Brain Tumor Center, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA.
Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
ORCID: 0000-0002-1751-8493

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Multiomic and clinical analysis of multiply...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs des méninges › Méningiome › Multiomic and clinical analysis of multiply...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Multiomic and clinical analysis of multiply...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Récidive tumorale locale › Multiomic and clinical analysis of multiply...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Multiomic and clinical analysis of multiply...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Multiomic and clinical analysis of multiply...
questionsmedicales.fr › Maladies du système nerveux › Tumeurs du système nerveux › Tumeurs du système nerveux central › Tumeurs des méninges › Multiomic and clinical analysis of multiply...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Variation structurale du génome › Variations de nombre de copies de segment d'ADN › Multiomic and clinical analysis of multiply...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Multiomic and clinical analysis of multiply...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Multiomic and clinical analysis of multiply...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Multiomic and clinical analysis of multiply...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Multiomic and clinical analysis of multiply...