Future Directions in Therapies for Acute Respiratory Distress Syndrome.

Humans Respiratory Distress Syndrome / therapy
ARDS Inflammation Phenotype Treatment

Journal

Clinics in chest medicine
ISSN: 1557-8216
Titre abrégé: Clin Chest Med
Pays: United States
ID NLM: 7907612

Informations de publication

Date de publication:
Dec 2024
Historique:
medline: 24 10 2024
pubmed: 24 10 2024
entrez: 23 10 2024
Statut: ppublish

Résumé

Acute respiratory distress syndrome (ARDS) is caused by a complex interplay among hyperinflammation, endothelial dysfunction, and alveolar epithelial injury. Targeted treatments toward the underlying pathways have been unsuccessful in unselected patient populations. The first reliable biological subphenotypes reflective of these biological disease states have been identified in the past decade. Subphenotype targeted intervention studies are needed to advance the pharmacologic treatment of ARDS.

Identifiants

DOI: 10.1016/j.ccm.2024.08.014 PMID: 39443010
pubmed: 39443010
pii: S0272-5231(24)00076-5
doi: 10.1016/j.ccm.2024.08.014
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

943-951

Informations de copyright

Copyright © 2024 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure L. D.J. Bos reports funding from Health Holland, Longfonds, ZonMw, Innovative Medicine Initiative and has consulted for Astra Zeneca, Pfizer, Sobi, Novartis, CSL Behring, Scailyte, and Santhera. All financial contributions were paid to the institution. J.E. Millar and K. Reddy declare no COI.

Auteurs

Jonathan E Millar (JE)

Baillie-Gifford Pandemic Science Hub, Centre for Inflammation Research, Institute for Repair and Regeneration, University of Edinburgh, The Roslin Institute, Easter Bush Campus, Midlothian, Edinburgh EH25 9RG, UK; Department of Critical Care, Queen Elizabeth University Hospital, Glasgow, UK.

Kiran Reddy (K)

Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, University Road, Belfast BT7 1NN, UK.

Lieuwe D J Bos (LDJ)

Intensive Care Department, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands. Electronic address: l.d.bos@amsterdamumc.nl.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Future Directions in Therapies for Acute...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Troubles respiratoires › Syndrome de détresse respiratoire de l'adulte › Future Directions in Therapies for Acute...