A unique and biocompatible corneal collagen crosslinking in vivo.
Blue light
Collagen
Cornea
Crosslinking
In vivo
Ruthenium
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
23 10 2024
23 10 2024
Historique:
received:
20
05
2024
accepted:
02
09
2024
medline:
24
10
2024
pubmed:
24
10
2024
entrez:
23
10
2024
Statut:
epublish
Résumé
Corneal crosslinking (CXL) is a widely applied technique to halt the progression of ectatic diseases through increasing the thickness and mechanical stiffness of the cornea. This study investigated the biocompatibility and efficiency of a novel CXL procedure using ruthenium and blue light in rat corneas and evaluated parameters important for clinical application. To perform the CXL procedure, the corneal epithelium of rats was removed under anaesthesia, followed by the application of a solution containing ruthenium and sodium persulfate (SPS). The corneas were then exposed to blue light at 430 nm at 3 mW/cm
Identifiants
pubmed: 39443505
doi: 10.1038/s41598-024-71871-9
pii: 10.1038/s41598-024-71871-9
doi:
Substances chimiques
Collagen
9007-34-5
Cross-Linking Reagents
0
Biocompatible Materials
0
Ruthenium
7UI0TKC3U5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
25042Subventions
Organisme : Türkiye Bilimsel ve Teknolojik Araştırma Kurumu
ID : 219S349
Informations de copyright
© 2024. The Author(s).
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