Integrating an antimicrobial nanocomposite to bioactive electrospun fibers for improved wound dressing materials.

Nanocomposites / chemistry Bandages Wound Healing / drug effects Graphite / chemistry Chitosan / chemistry Silver / chemistry Polyesters / chemistry Povidone / chemistry Anti-Infective Agents / pharmacology Metal Nanoparticles / chemistry Humans Biocompatible Materials / chemistry Anti-Bacterial Agents / pharmacology Burns / drug therapy Nanofibers / chemistry Microbial Sensitivity Tests
Chitosan Electrospinning Graphene oxide Silver nanocrystal Wound dressings

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
24 10 2024
Historique:
received: 02 05 2024
accepted: 08 10 2024
medline: 24 10 2024
pubmed: 24 10 2024
entrez: 24 10 2024
Statut: epublish

Résumé

This study investigates the fabrication and characterization of electrospun poly (ε-caprolactone)/poly (vinyl pyrrolidone) (PCL/PVP) fibers integrated with a nanocomposite of chitosan, silver nanocrystals, and graphene oxide (ChAgG), aimed at developing advanced wound dressing materials. The ChAgG nanocomposite, recognized for its antimicrobial and biocompatible properties, was incorporated into PCL/PVP fibers through electrospinning techniques. We assessed the resultant fibers' morphological, physicochemical, and mechanical properties, which exhibited significant enhancements in mechanical strength and demonstrated effective antimicrobial activity against common bacterial pathogens. The findings suggest that the PCL/PVP-ChAgG fibers maintain biocompatibility and facilitate controlled therapeutic delivery, positioning them as a promising solution for managing chronic and burn-related wounds. This study underscores the potential of these advanced materials to improve healing outcomes cost-effectively, particularly in settings plagued by high incidences of burn injuries. Further clinical investigations are recommended to explore these innovative fibers' full potential and real-world applicability.

Identifiants

DOI: 10.1038/s41598-024-75814-2 PMID: 39443526
pubmed: 39443526
doi: 10.1038/s41598-024-75814-2
pii: 10.1038/s41598-024-75814-2
doi:

Substances chimiques

Graphite 7782-42-5
Chitosan 9012-76-4
Silver 3M4G523W1G
Polyesters 0
polycaprolactone 24980-41-4
graphene oxide 0
Povidone FZ989GH94E
Anti-Infective Agents 0
Biocompatible Materials 0
Anti-Bacterial Agents 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

25118

Subventions

Organisme : CONCyTEP
ID : 2021 TecNM
Organisme : CONCyTEP
ID : 2021 TecNM
Organisme : CONCyTEP
ID : 2021 TecNM
Organisme : CONCyTEP
ID : 2021 TecNM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Victoria Leonor Reyes-Guzmán (VL)

Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Blvd. Universitario, #1000. Unidad Valle de las Palmas. Tijuana, Baja, Tijuana, CP. 21500, Baja California, México.

Luis Jesús Villarreal-Gómez (LJ)

Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Blvd. Universitario, #1000. Unidad Valle de las Palmas. Tijuana, Baja, Tijuana, CP. 21500, Baja California, México. luis.villarreal@uabc.edu.mx.
Facultad de Ciencias Química e Ingeniería, Universidad Autónoma de Baja California, Universidad #14418, UABC, Parque Internacional Industrial Tijuana, Tijuana, 22424, Baja California, México. luis.villarreal@uabc.edu.mx.

Rubi Vázquez-Mora (R)

Tecnológico Nacional de México, Unidad Tecnológica Acatlán, Campús Acatlán de Osorio, Carretera Acatlán - San Juan Ixcaquistla kilómetro 5.5, Del Maestro, Acatlán, 74949, Puebla, México.

Yesica Itzel Méndez-Ramírez (YI)

Tecnológico Nacional de México, Unidad Tecnológica Acatlán, Campús Acatlán de Osorio, Carretera Acatlán - San Juan Ixcaquistla kilómetro 5.5, Del Maestro, Acatlán, 74949, Puebla, México.

Juan Antonio Paz-González (JA)

Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Blvd. Universitario, #1000. Unidad Valle de las Palmas. Tijuana, Baja, Tijuana, CP. 21500, Baja California, México.

Arturo Zizumbo-López (A)

Tecnológico Nacional de México, Campus Tijuana, Blvd. Alberto Limón Padilla y Av. ITR Tijuana S/N, Colonia Mesa de Otay, Tijuana, C.P. 22500, Baja California, México.

Hugo Borbón (H)

Centro de Nanociencias y Nanotecnología, Universidad Nacional Autónoma de México, Carr. Tijuana-Ensenada km107, C.I.C.E.S.E, Ensenada, 22860, Baja California, México.

Eder Germán Lizarraga-Medina (EG)

Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Blvd. Universitario, #1000. Unidad Valle de las Palmas. Tijuana, Baja, Tijuana, CP. 21500, Baja California, México.

José Manuel Cornejo-Bravo (JM)

Facultad de Ciencias Química e Ingeniería, Universidad Autónoma de Baja California, Universidad #14418, UABC, Parque Internacional Industrial Tijuana, Tijuana, 22424, Baja California, México.

Graciela Lizeth Pérez-González (GL)

Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Blvd. Universitario, #1000. Unidad Valle de las Palmas. Tijuana, Baja, Tijuana, CP. 21500, Baja California, México.

Arturo Sinue Ontiveros-Zepeda (AS)

Facultad de Ciencias de la Ingeniería, Administrativas y Sociales, Universidad Autónoma de Baja California, Blvrd Universidad 1, San Fernando, Tecate, 21460, Baja California, México.

Armando Pérez-Sánchez (A)

Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Blvd. Universitario, #1000. Unidad Valle de las Palmas. Tijuana, Baja, Tijuana, CP. 21500, Baja California, México.

Elizabeth Chavira-Martínez (E)

Instituto de Investigaciones en Materiales, Circuito Exterior S/N Circuito de la Investigación Científica, C.U, Ciudad de México, 04510, México. chavira@unam.mx.

Rafael Huirache-Acuña (R)

Facultad de Ingeniería Química, Universidad Michoacana de San Nicolás de Hidalgo, Michoacán, 58060, Morelia, Mexico.

Yoxkin Estévez-Martínez (Y)

Tecnológico Nacional de México, Unidad Tecnológica Acatlán, Campús Acatlán de Osorio, Carretera Acatlán - San Juan Ixcaquistla kilómetro 5.5, Del Maestro, Acatlán, 74949, Puebla, México. yoxkin@gmail.com.

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Classifications MeSH

questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanocomposites › Integrating an antimicrobial nanocomposite to...
questionsmedicales.fr › Équipement et fournitures › Bandages › Integrating an antimicrobial nanocomposite to...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Cicatrisation de plaie › Integrating an antimicrobial nanocomposite to...
questionsmedicales.fr › Produits chimiques inorganiques › Minéraux › Graphite › Integrating an antimicrobial nanocomposite to...
questionsmedicales.fr › Glucides › Polyosides › Chitine › Chitosane › Integrating an antimicrobial nanocomposite to...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Argent › Integrating an antimicrobial nanocomposite to...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyesters › Integrating an antimicrobial nanocomposite to...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Matières plastiques › Polyvinyles › Povidone › Integrating an antimicrobial nanocomposite to...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Integrating an antimicrobial nanocomposite to...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Nanoparticules métalliques › Integrating an antimicrobial nanocomposite to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Integrating an antimicrobial nanocomposite to...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Matériaux biocompatibles › Integrating an antimicrobial nanocomposite to...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Integrating an antimicrobial nanocomposite to...
questionsmedicales.fr › Plaies et blessures › Brûlures › Integrating an antimicrobial nanocomposite to...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanofibres › Integrating an antimicrobial nanocomposite to...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Integrating an antimicrobial nanocomposite to...