Nasal obstruction during development leads to defective synapse elimination, hypersynchrony, and impaired cerebellar function.


Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
23 Oct 2024
Historique:
received: 16 03 2024
accepted: 17 10 2024
medline: 24 10 2024
pubmed: 24 10 2024
entrez: 24 10 2024
Statut: epublish

Résumé

Nasal respiratory disorders are linked to craniofacial anomalies and systemic dysfunctions. However, the implications of nasal respiratory disorders on brain development and their subsequent impact on brain functionalization remain largely unknown. Here, we describe that nasal obstruction from postnatal developmental stages in mice precipitates deficits in cerebellum-associated behaviors and compromised refinement and maturation of neural circuits in the cerebellum. We show that mice with nasal obstruction during developmental phases exhibit marked impairments in motor function and exhibit increased immobility time in forced swimming test. Additionally, we identified critical periods during which nasal respiration is essential for optimizing motor function and preserving mental health. Our study also reveals that nasal obstruction in mice disrupts the typical developmental process of synapse elimination in the cerebellum and hinders the normal transition of activity patterns in cerebellar Purkinje cell populations during development. Through comparing activity patterns in mouse models subjected to nasal obstruction at various stages, we suggest that the maturation of specific activity pattern among Purkinje cell populations is fundamental to the functional integrity of the cerebellum. Our findings highlight the indispensable role of adequate nasal respiration during development for the establishment and functional integrity of neural circuits, thereby significantly affecting brain function.

Identifiants

pubmed: 39443666
doi: 10.1038/s42003-024-07095-4
pii: 10.1038/s42003-024-07095-4
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1381

Subventions

Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 22H05092
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 22H05093
Organisme : Ministry of Education, Culture, Sports, Science and Technology (MEXT)
ID : JPMJFS2109

Informations de copyright

© 2024. The Author(s).

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Auteurs

Moe Tanigawa (M)

Department of Cognitive Neurobiology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.

Mengke Liu (M)

Department of Cognitive Neurobiology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.

Mariko Sekiguchi (M)

Department of Cognitive Neurobiology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.

Kyosuke Goda (K)

Department of Cognitive Neurobiology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.

Chiho Kato (C)

Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.

Takashi Ono (T)

Department of Orthodontic Science, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.

Naofumi Uesaka (N)

Department of Cognitive Neurobiology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan. uesaka.cnb@tmd.ac.jp.

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