Examining the healthy human microbiome concept.

Journal

Nature reviews. Microbiology

ISSN: 1740-1534

Titre abrégé: Nat Rev Microbiol

Pays: England

ID NLM: 101190261

Informations de publication

Date de publication:
23 Oct 2024

Historique:

accepted: 04 09 2024

medline: 24 10 2024

pubmed: 24 10 2024

entrez: 24 10 2024

Statut: aheadofprint

Résumé

Human microbiomes are essential to health throughout the lifespan and are increasingly recognized and studied for their roles in metabolic, immunological and neurological processes. Although the full complexity of these microbial communities is not fully understood, their clinical and industrial exploitation is well advanced and expanding, needing greater oversight guided by a consensus from the research community. One of the most controversial issues in microbiome research is the definition of a 'healthy' human microbiome. This concept is complicated by the microbial variability over different spatial and temporal scales along with the challenge of applying a unified definition to the spectrum of healthy microbiome configurations. In this Perspective, we examine the progress made and the key gaps that remain to be addressed to fully harness the benefits of the human microbiome. We propose a road map to expand our knowledge of the microbiome-health relationship, incorporating epidemiological approaches informed by the unique ecological characteristics of these communities.

Identifiants

DOI: 10.1038/s41579-024-01107-0 PMID: 39443812

pubmed: 39443812

doi: 10.1038/s41579-024-01107-0

pii: 10.1038/s41579-024-01107-0

doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

Investigateurs

Francesco Asnicar (F)

Athanasios Typas (A)

Fay Betsou (F)

Hervé Blottière (H)

Peer Bork (P)

Isabelle Boutron (I)

Federica Carraturo (F)

Marcus Claesson (M)

Magali Cordaillat-Simmons (M)

Celine Druart (C)

Alessio Fasano (A)

Yolanda Godoy (Y)

Dirk Haller (D)

Zahra Hassani (Z)

Diënty H M J Hazenbrink (DHMJ)

Mads Israelsen (M)

Anandhi Iyappan (A)

Alexander Jarde (A)

Stephan Kampshoff (S)

Aleksander Krag (A)

Aicha Kriaa (A)

Aonghus Lavelle (A)

Amira Metwaly (A)

Vitalina Morozova (V)

Federica Pinto (F)

Nicolas Pons (N)

Pierre-Louis Prost (PL)

Philippe Ravaud (P)

Moez Rhimi (M)

Julie Rodriquez (J)

Arjun Sarati (A)

Robert Schierwagen (R)

Nicola Segata (N)

Debora Serra (D)

Jonel Trebicka (J)

Corrado Vecchi (C)

Patrick Veiga (P)

Laurence Zitvogel (L)

Lisa Derosa (L)

Informations de copyright

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