Borderline personality disorder and post-traumatic stress disorder in adolescents: protocol for a comparative study of borderline personality disorder with and without comorbid post-traumatic stress disorder (BORDERSTRESS-ADO).

Adolescent Female Humans Borderline Personality Disorder / complications Comorbidity Hippocampus / pathology Magnetic Resonance Imaging Stress Disorders, Post-Traumatic / epidemiology
Adolescent Borderline personality disorder Comorbidity Emotional regulation Female Hippocampus Neuroanatomy Post-traumatic stress disorder Psychopathology

Journal

BMC psychiatry
ISSN: 1471-244X
Titre abrégé: BMC Psychiatry
Pays: England
ID NLM: 100968559

Informations de publication

Date de publication:
23 Oct 2024
Historique:
received: 19 07 2024
accepted: 18 09 2024
medline: 24 10 2024
pubmed: 24 10 2024
entrez: 24 10 2024
Statut: epublish

Résumé

Borderline Personality Disorder (BPD) is a prevalent and debilitating psychiatric condition often accompanied by Post-Traumatic Stress Disorder (PTSD), with a substantial prevalence of trauma history among affected individuals. The clinical, cognitive, and cerebral parallels shared with PTSD suggest a trauma-related etiology for BPD. Studies consistently demonstrate a reduction in hippocampal volume in individuals with BPD, echoing findings in PTSD. However, the interpretation of this shared neurobiological profile remains contentious, with ongoing debates regarding the independence of these pathologies or the potential exacerbation of diminished hippocampal volume in BPD due to concurrent PTSD. Differential impacts on hippocampal subfields across both disorders may further complicate interpretation, suggesting the volume of hippocampal subfields as a potential discriminant biomarker. This study aims to characterize the multidimensional specific and shared profiles of BPD and PTSD-related alterations, with a particular emphasis on hippocampal subfields during adolescence, a crucial period in BPD development. This study focuses on female adolescents, who are more prevalent in the BPD population. Participants are categorized into three groups: BPD, BPD with comorbid PTSD, and a control group of matched healthy individuals. Data collection encompasses clinical, cognitive, and neuroimaging domains commonly affected in both disorders, utilizing various imaging markers (including gray matter macrostructure, white matter microstructural integrity, and regional functional connectivity). This study examines adolescent BPD with and without comorbid PTSD on clinical, neuroimaging, and cognitive levels. It is the first to use a comprehensive multi-modal approach within the same sample. Additionally, it uniquely explores hippocampal subfield volume differences in adolescents. Analysis of the relationship between the investigated domains and the effects of PTSD comorbidity will elucidate specific and shared alteration profiles in both disorders. IDRCB number 2019-A00366-51 / clinicaltrials.gov ID: NCT0485274. Registered on 21/04/2021.

Sections du résumé

BACKGROUND BACKGROUND
Borderline Personality Disorder (BPD) is a prevalent and debilitating psychiatric condition often accompanied by Post-Traumatic Stress Disorder (PTSD), with a substantial prevalence of trauma history among affected individuals. The clinical, cognitive, and cerebral parallels shared with PTSD suggest a trauma-related etiology for BPD. Studies consistently demonstrate a reduction in hippocampal volume in individuals with BPD, echoing findings in PTSD. However, the interpretation of this shared neurobiological profile remains contentious, with ongoing debates regarding the independence of these pathologies or the potential exacerbation of diminished hippocampal volume in BPD due to concurrent PTSD. Differential impacts on hippocampal subfields across both disorders may further complicate interpretation, suggesting the volume of hippocampal subfields as a potential discriminant biomarker. This study aims to characterize the multidimensional specific and shared profiles of BPD and PTSD-related alterations, with a particular emphasis on hippocampal subfields during adolescence, a crucial period in BPD development.
METHODS METHODS
This study focuses on female adolescents, who are more prevalent in the BPD population. Participants are categorized into three groups: BPD, BPD with comorbid PTSD, and a control group of matched healthy individuals. Data collection encompasses clinical, cognitive, and neuroimaging domains commonly affected in both disorders, utilizing various imaging markers (including gray matter macrostructure, white matter microstructural integrity, and regional functional connectivity).
DISCUSSION CONCLUSIONS
This study examines adolescent BPD with and without comorbid PTSD on clinical, neuroimaging, and cognitive levels. It is the first to use a comprehensive multi-modal approach within the same sample. Additionally, it uniquely explores hippocampal subfield volume differences in adolescents. Analysis of the relationship between the investigated domains and the effects of PTSD comorbidity will elucidate specific and shared alteration profiles in both disorders.
TRIAL REGISTRATION BACKGROUND
IDRCB number 2019-A00366-51 / clinicaltrials.gov ID: NCT0485274. Registered on 21/04/2021.

Identifiants

DOI: 10.1186/s12888-024-06093-4 PMID: 39443885
pubmed: 39443885
doi: 10.1186/s12888-024-06093-4
pii: 10.1186/s12888-024-06093-4
doi:

Types de publication

Clinical Study Comparative Study Journal Article Multicenter Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

724

Subventions

Organisme : - Programme Hospitalier de Recherche Clinique Inter-régional (GIRCI, PHRCI)
ID : API 18-15

Informations de copyright

© 2024. The Author(s).

Références

Bohus M, Stoffers-Winterling J, Sharp C, Krause-Utz A, Schmahl C, Lieb K. Borderline personality disorder. Lancet Lond Engl. 2021;398(10310):1528–40.
doi: 10.1016/S0140-6736(21)00476-1
Leichsenring F, Heim N, Leweke F, Spitzer C, Steinert C, Kernberg OF. Borderline Personality Disorder: Rev JAMA. 2023;329(8):670–9.
American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5. 5th edition. Arlington, VA: American Psychiatric Association. 2013. 947 p.
Ellison WD, Rosenstein LK, Morgan TA, Zimmerman M. Community and clinical epidemiology of Borderline personality disorder. Psychiatr Clin North Am. 2018;41(4):561–73.
pubmed: 30447724 doi: 10.1016/j.psc.2018.07.008
Gunderson JG, Herpertz SC, Skodol AE, Torgersen S, Zanarini MC. Borderline personality disorder. Nat Rev Dis Primer. 2018;4(1):1–20.
doi: 10.1038/nrdp.2018.29
Stepp SD, Lazarus SA, Byrd AL. A systematic review of risk factors prospectively associated with borderline personality disorder: taking stock and moving forward. Personal Disord Theory Res Treat. 2016;7(4):316–23.
doi: 10.1037/per0000186
Frías Á, Palma C. Comorbidity between post-traumatic stress disorder and Borderline personality disorder: a review. Psychopathology. 2015;48(1):1–10.
pubmed: 25227722 doi: 10.1159/000363145
Barnicot K, Crawford M. Posttraumatic stress disorder in patients with Borderline personality disorder: treatment outcomes and mediators. J Trauma Stress. 2018;31(6):899–908.
pubmed: 30398678 doi: 10.1002/jts.22340
Battle CL, Shea MT, Johnson DM, Yen S, Zlotnick C, Zanarini MC, et al. Childhood maltreatment Associated with Adult Personality disorders: findings from the collaborative Longitudinal Personality disorders Study. J Personal Disord. 2004;18(2):193–211.
doi: 10.1521/pedi.18.2.193.32777
Porter C, Palmier-Claus J, Branitsky A, Mansell W, Warwick H, Varese F. Childhood adversity and borderline personality disorder: a meta-analysis. Acta Psychiatr Scand. 2020;141(1):6–20.
pubmed: 31630389 doi: 10.1111/acps.13118
Sharp C, Kim S. Recent advances in the Developmental aspects of Borderline personality disorder. Curr Psychiatry Rep. 2015;17(4):21.
doi: 10.1007/s11920-015-0556-2
Fonagy P, Luyten P, Allison E, Campbell C. What we have changed our minds about: part 2. Borderline personality disorder, epistemic trust and the developmental significance of social communication. Borderline Personal Disord Emot Dysregulation. 2017;4(1):9.
doi: 10.1186/s40479-017-0062-8
Schweizer S, Gotlib IH, Blakemore SJ. The role of affective control in emotion regulation during adolescence. Emotion. 2020;20(1):80.
Branje S, de Moor EL, Spitzer J, Becht AI. Dynamics of Identity Development in Adolescence: a decade in review. J Res Adolesc. 2021;31(4):908–27.
pubmed: 34820948 pmcid: 9298910 doi: 10.1111/jora.12678
Kilford EJ, Garrett E, Blakemore, Sarah-Jayne. The development of social cognition in adolescence: an integrated perspective. Neurosci Biobehav Rev. 2016;70:106–20.
pubmed: 27545755 doi: 10.1016/j.neubiorev.2016.08.016
Constantinidis C, Luna B. Neural substrates of Inhibitory Control Maturation in Adolescence. Trends Neurosci. 2019;42(9):604–16.
pubmed: 31443912 pmcid: 6721973 doi: 10.1016/j.tins.2019.07.004
Chanen AM, Velakoulis D, Carison K, Gaunson K, Wood SJ, Yuen HP, et al. Orbitofrontal, amygdala and hippocampal volumes in teenagers with first-presentation borderline personality disorder. Psychiatry Res Neuroimaging. 2008;163(2):116–25.
doi: 10.1016/j.pscychresns.2007.08.007
Whittle S, Chanen AM, Fornito A, McGorry PD, Pantelis C, Yücel M. Anterior cingulate volume in adolescents with first-presentation borderline personality disorder. Psychiatry Res. 2009;172(2):155–60.
pubmed: 19299113 doi: 10.1016/j.pscychresns.2008.12.004
Brunner R, Henze R, Parzer P, Kramer J, Feigl N, Lutz K, et al. Reduced prefrontal and orbitofrontal gray matter in female adolescents with borderline personality disorder: is it disorder specific? NeuroImage. 2010;49(1):114–20.
pubmed: 19660555 doi: 10.1016/j.neuroimage.2009.07.070
Goodman M, Hazlett EA, Avedon JB, Siever DR, Chu KW, New AS. Anterior cingulate volume reduction in adolescents with borderline personality disorder and co-morbid major depression. J Psychiatr Res. 2011;45(6):803–7.
pubmed: 21145068 doi: 10.1016/j.jpsychires.2010.11.011
Maier-Hein KH, Brunner R, Lutz K, Henze R, Parzer P, Feigl N, et al. Disorder-specific white matter alterations in adolescent Borderline personality disorder. Biol Psychiatry. 2014;75(1):81–8.
pubmed: 23768862 doi: 10.1016/j.biopsych.2013.03.031
Xiao Q, Fu Y, Yi X, Ding J, Han Z, Zhang Z, et al. Altered cortical thickness and emotional dysregulation in adolescents with borderline personality disorder. Eur J Psychotraumatology. 2023;14(1):2163768.
doi: 10.1080/20008066.2022.2163768
Jovev M, Whittle S, Yücel M, Simmons JG, Allen NB, Chanen AM. The relationship between hippocampal asymmetry and temperament in adolescent borderline and antisocial personality pathology. Dev Psychopathol. 2014;26(1):275–85.
pubmed: 24274051 doi: 10.1017/S0954579413000886
Richter J, Brunner R, Parzer P, Resch F, Stieltjes B, Henze R. Reduced cortical and subcortical volumes in female adolescents with borderline personality disorder. Psychiatry Res. 2014;221(3):179–86.
pubmed: 24503371 doi: 10.1016/j.pscychresns.2014.01.006
Ruocco AC, Carcone D. A neurobiological model of Borderline personality disorder: systematic and integrative review. Harv Rev Psychiatry. 2016;24(5):311–29.
pubmed: 27603741 doi: 10.1097/HRP.0000000000000123
Kelleher-Unger I, Tajchman Z, Chittano G, Vilares I. Meta-analysis of white matter diffusion tensor imaging alterations in borderline personality disorder. Psychiatry Res Neuroimaging. 2021;307:111205.
pubmed: 33158715 doi: 10.1016/j.pscychresns.2020.111205
Lou J, Sun Y, Cui Z, Gong L. Common and distinct patterns of gray matter alterations in borderline personality disorder and posttraumatic stress disorder: a dual meta-analysis. Neurosci Lett. 2021;741:135376.
pubmed: 33221476 doi: 10.1016/j.neulet.2020.135376
Kunimatsu A, Yasaka K, Akai H, Kunimatsu N, Abe O. MRI findings in posttraumatic stress disorder. J Magn Reson Imaging. 2020;52(2):380–96.
pubmed: 31515885 doi: 10.1002/jmri.26929
Del Casale A, Ferracuti S, Barbetti AS, Bargagna P, Zega P, Iannuccelli A, et al. Grey Matter volume reductions of the Left Hippocampus and Amygdala in PTSD: a coordinate-based Meta-analysis of magnetic resonance Imaging studies. Neuropsychobiology. 2022;81(4):257–64.
pubmed: 35158360 doi: 10.1159/000522003
Dennis EL, Disner SG, Fani N, Salminen LE, Logue M, Clarke EK, et al. Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium. Mol Psychiatry. 2021;26(8):4315–30.
pubmed: 31857689 doi: 10.1038/s41380-019-0631-x
Visintin E, De Panfilis C, Amore M, Balestrieri M, Wolf RC, Sambataro F. Mapping the brain correlates of borderline personality disorder: a functional neuroimaging meta-analysis of resting state studies. J Affect Disord. 2016;204:262–9.
pubmed: 27552444 doi: 10.1016/j.jad.2016.07.025
Amad A, Radua J, Vaiva G, Williams SC, Fovet T. Similarities between borderline personality disorder and post traumatic stress disorder: evidence from resting-state meta-analysis. Neurosci Biobehav Rev. 2019;105:52–9.
pubmed: 31369796 doi: 10.1016/j.neubiorev.2019.07.018
Nunes PM, Wenzel A, Borges KT, Porto CR, Caminha RM, de Oliveira IR. Volumes of the Hippocampus and Amygdala in patients with Borderline personality disorder: a Meta-analysis. J Personal Disord. 2009;23(4):333–45.
doi: 10.1521/pedi.2009.23.4.333
Ruocco AC, Amirthavasagam S, Zakzanis KK. Amygdala and hippocampal volume reductions as candidate endophenotypes for borderline personality disorder: a meta-analysis of magnetic resonance imaging studies. Psychiatry Res Neuroimaging. 2012;201(3):245–52.
doi: 10.1016/j.pscychresns.2012.02.012
Yang X, Hu L, Zeng J, Tan Y, Cheng B. Default mode network and frontolimbic gray matter abnormalities in patients with borderline personality disorder: a voxel-based meta-analysis. Sci Rep. 2016;6(1):34247.
pubmed: 27694955 pmcid: 5046132 doi: 10.1038/srep34247
Davidson RJ, Fox A, Kalin NH. Neural bases of emotion regulation in Nonhuman Primates and humans. Handbook of emotion regulation. New York, NY, US: The Guilford Press; 2007. pp. 47–68.
Mitchell MR, Potenza MN. Recent insights into the Neurobiology of Impulsivity. Curr Addict Rep. 2014;1(4):309–19.
pubmed: 25431750 pmcid: 4242429 doi: 10.1007/s40429-014-0037-4
Pattij T, Vanderschuren LJMJ. The neuropharmacology of impulsive behaviour. Trends Pharmacol Sci. 2008;29(4):192–9.
pubmed: 18304658 doi: 10.1016/j.tips.2008.01.002
Lisman J, Buzsáki G, Eichenbaum H, Nadel L, Ranganath C, Redish AD. Viewpoints: how the hippocampus contributes to memory, navigation and cognition. Nat Neurosci. 2017;20(11):1434–47.
pubmed: 29073641 pmcid: 5943637 doi: 10.1038/nn.4661
Montagrin A, Saiote C, Schiller D. The social hippocampus. Hippocampus. 2018;28(9):672–9.
pubmed: 28843041 doi: 10.1002/hipo.22797
Chaposhloo M, Nicholson AA, Becker S, McKinnon MC, Lanius R, Shaw SB, et al. Altered resting-state functional connectivity in the anterior and posterior hippocampus in post-traumatic stress disorder: the central role of the anterior hippocampus. NeuroImage Clin. 2023;38:103417.
pubmed: 37148709 pmcid: 10193024 doi: 10.1016/j.nicl.2023.103417
Gilbertson MW, Shenton ME, Ciszewski A, Kasai K, Lasko NB, Orr SP, et al. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nat Neurosci. 2002;5(11):1242–7.
pubmed: 12379862 pmcid: 2819093 doi: 10.1038/nn958
van Rooij SJH, Stevens JS, Ely TD, Hinrichs RC, Michopoulos V, Winters SJ, et al. The role of the hippocampus in predicting future PTSD symptoms in recently traumatized civilians. Biol Psychiatry. 2018;84(2):106–15.
pubmed: 29110899 doi: 10.1016/j.biopsych.2017.09.005
Keding TJ, Herringa RJ. Abnormal structure of fear circuitry in Pediatric post-traumatic stress disorder. Neuropsychopharmacology. 2015;40(3):537–45.
pubmed: 25212487 doi: 10.1038/npp.2014.239
Malhi GS, Das P, Outhred T, Irwin L, Gessler D, Bwabi Z, et al. The effects of childhood trauma on adolescent hippocampal subfields. Aust N Z J Psychiatry. 2019;53(5):447–57.
pubmed: 30712362 doi: 10.1177/0004867418824021
Frodl T, O’Keane V. How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans. Neurobiol Dis. 2013;52:24–37.
pubmed: 22426398 doi: 10.1016/j.nbd.2012.03.012
Teicher MH, Anderson CM, Polcari A. Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum. Proc Natl Acad Sci U S A. 2012;109(9):E563–572.
pubmed: 22331913 pmcid: 3295326 doi: 10.1073/pnas.1115396109
Niedtfelt I, Schulze L, Krause-Utz A, Demirakca T, Bohus M, Schmahl C. Voxel-based morphometry in women with Borderline personality disorder with and without Comorbid Posttraumatic stress disorder. PLoS ONE. 2013;8(6):e65824.
doi: 10.1371/journal.pone.0065824
Schmahl CG, Vermetten E, Elzinga BM, Douglas Bremner J. Magnetic resonance imaging of hippocampal and amygdala volume in women with childhood abuse and borderline personality disorder. Psychiatry Res Neuroimaging. 2003;122(3):193–8.
doi: 10.1016/S0925-4927(03)00023-4
Weniger G, Lange C, Sachsse U, Irle E. Reduced amygdala and hippocampus size in trauma-exposed women with borderline personality disorder and without posttraumatic stress disorder. J Psychiatry Neurosci JPN. 2009;34(5):383–8.
pubmed: 19721849
Zetzsche T, Preuss UW, Frodl T, Schmitt G, Seifert D, Münchhausen E, et al. Hippocampal volume reduction and history of aggressive behaviour in patients with borderline personality disorder. Psychiatry Res Neuroimaging. 2007;154(2):157–70.
doi: 10.1016/j.pscychresns.2006.05.010
Rodrigues E, Wenzel A, Ribeiro MP, Quarantini LC, Miranda-Scippa A, de Sena EP, et al. Hippocampal volume in borderline personality disorder with and without comorbid posttraumatic stress disorder: a meta-analysis. Eur Psychiatry. 2011;26(7):452–6.
pubmed: 20933369 doi: 10.1016/j.eurpsy.2010.07.005
Postel C, Viard A, André C, Guénolé F, de Flores R, Baleyte J, et al. Hippocampal subfields alterations in adolescents with post-traumatic stress disorder. Hum Brain Mapp. 2018;40(4):1244–52.
pubmed: 30367743 pmcid: 6865506 doi: 10.1002/hbm.24443
Bøen E, Westlye LT, Elvsåshagen T, Hummelen B, Hol PK, Boye B, et al. Smaller stress-sensitive hippocampal subfields in women with borderline personality disorder without posttraumatic stress disorder. J Psychiatry Neurosci JPN. 2014;39(2):127–34.
pubmed: 24309162
Soper DS. A-priori Sample Size for Student t-Tests. [cited 2024 Jul 22]. https://www.danielsoper.com/statcalc
Klein DN, Ouimette PC, Kelly HS, Ferro T, Riso LP. Test-retest reliability of team consensus best-estimate diagnoses of axis I and II disorders in a family study. Am J Psychiatry. 1994;151(7):1043–7.
pubmed: 8010362 doi: 10.1176/ajp.151.7.1043
Pfohl B, Blum N, Zimmerman M, Personality. SIDP-IV. American Psychiatric Pub; 1997. 50.
Kaufman J, Birmaher B, Axelson D, Perepletchikova F, Brent D, Ryan N. K-SADS-PL DSM-5. Pittsburgh: Western Psychiatric Institute and Clinic; 2016.
Shaffer D, Gould MS, Brasic J, Ambrosini P, Fisher P, Bird H, et al. A children’s global assessment scale (CGAS). Arch Gen Psychiatry. 1983;40(11):1228–31.
pubmed: 6639293 doi: 10.1001/archpsyc.1983.01790100074010
Kaplow JB, Rolon-Arroyo B, Layne CM, Rooney E, Oosterhoff B, Hill R, et al. Validation of the UCLA PTSD reaction index for DSM-5: a developmentally informed Assessment Tool for Youth. J Am Acad Child Adolesc Psychiatry. 2020;59(1):186–94.
pubmed: 30953734 doi: 10.1016/j.jaac.2018.10.019
Revah-Levy A, Birmaher B, Gasquet I, Falissard B. The adolescent Depression Rating Scale (ADRS): a validation study. BMC Psychiatry. 2007;7(1):2.
pubmed: 17222346 pmcid: 1785378 doi: 10.1186/1471-244X-7-2
Ensink K, Bégin M, Kotiuga J, Sharp C, Normandin L. Psychometric properties of the French Version of the Borderline personality features scale for children and adolescents. Adolesc Psychiatry. 2020;10(1):48–58.
doi: 10.2174/2210676609666190820145256
Sharp C, Steinberg L, Temple J, Newlin E. An 11-item measure to assess borderline traits in adolescents: refinement of the BPFSC using IRT. Personal Disord Theory Res Treat. 2014;5(1):70–8.
doi: 10.1037/per0000057
Wechsler D. Échelle d’intelligence de Wechsler pour enfants et adolescents, 5ème édition (WISC-V)—Adaptation française. ECPA Par Pearson. 2016.
Wechsler D. WAIS-IV Nouvelle version de l’échelle d’intelligence de wechsler pour adultes. Paris Ed Cent Psychol Appliquée; 2011.
Bernstein DP, Ahluvalia T, Pogge D, Handelsman L. Validity of the Childhood Trauma Questionnaire in an adolescent Psychiatric Population. J Am Acad Child Adolesc Psychiatry. 1997;36(3):340–8.
pubmed: 9055514 doi: 10.1097/00004583-199703000-00012
Corcos M, Pham-Scottez A, Speranza M. Troubles de la personnalité borderline à l’adolescence. Paris (FR): Dunod. 2013.
Pierrehumbert B, Karmaniola A, Sieye A, Meister C, Miljkovitch R, Halfon O. Les modéles de relations: Développement d’un auto-questionnaire d’attachement pour adultes. Psychiatrie Enf. 1996;1:161–206.
Pahlavan F, Mouchiroud C, Zenasni F, Panksepp J. Validation De L’adaptation française de l’échelle neuro-affective de personnalité. Eur Rev Appl Psychol. 2008;58(3):155–63.
doi: 10.1016/j.erap.2007.08.004
Conners CK. CPT-II, continuous performance test II. Toronto. Ont Can Multi-Health Syst; 2002.
Heaton RK, Chelune GJ, Talley JL, Kay GG, Curtiss G. Wisconsin card sorting test manual. Odessa, Fla. Psychol Assess Resour. 1981.
Martinez G, Alexandre C, Mam-Lam-Fook C, Bendjemaa N, Gaillard R, Garel P, et al. Phenotypic continuum between autism and schizophrenia: evidence from the movie for the Assessment of Social Cognition (MASC). Schizophr Res. 2017;185:161–6.
pubmed: 28089135 doi: 10.1016/j.schres.2017.01.012
Badoud D, Luyten P, Fonseca-Pedrero E, Eliez S, Fonagy P, Debbané M. The French Version of the reflective functioning questionnaire: Validity Data for adolescents and adults and its Association with Non-suicidal Self-Injury. PLoS ONE. 2015;10(12):e0145892.
pubmed: 26714319 pmcid: 4694697 doi: 10.1371/journal.pone.0145892
Goth K, Foelsch P, Schlüter-Müller S, Birkhölzer M, Jung E, Pick O, et al. Assessment of identity development and identity diffusion in adolescence - theoretical basis and psychometric properties of the self-report questionnaire AIDA. Child Adolesc Psychiatry Ment Health. 2012;6(1):27.
pubmed: 22812911 pmcid: 3485126 doi: 10.1186/1753-2000-6-27
Reese E, Haden CA, Baker-Ward L, Bauer P, Fivush R, Ornstein PA. Coherence of personal narratives across the Lifespan: a Multidimensional Model and Coding Method. J Cogn Dev off J Cogn Dev Soc. 2011;12(4):424–62.
La Joie R, Fouquet M, Mézenge F, Landeau B, Villain N, Mevel K, et al. Differential effect of age on hippocampal subfields assessed using a new high-resolution 3T MR sequence. NeuroImage. 2010;53(2):506–14.
pubmed: 20600996 doi: 10.1016/j.neuroimage.2010.06.024
Chang C, Glover GH. Effects of model-based physiological noise correction on default mode network anti-correlations and correlations. NeuroImage. 2009;47(4):1448–59.
pubmed: 19446646 doi: 10.1016/j.neuroimage.2009.05.012
Schafer JL, Olsen MK. Multiple imputation for multivariate missing-data problems: A Data Analyst’s perspective. Multivar Behav Res. 1998;33(4):545–71.
doi: 10.1207/s15327906mbr3304_5

Auteurs

Maëlle Riou (M)

Université de Caen Normandie, Inserm, EPHE, PSL Université Paris, CHU de Caen, GIP Cyceron, U1077, NIMH, Caen, 14000, France.

Harmony Duclos (H)

CRP-CPO, UR UPJV 7273, Université de Picardie Jules Verne, Amiens, 80000, France.

Méline Leribillard (M)

Université de Caen Normandie, Inserm, EPHE, PSL Université Paris, CHU de Caen, GIP Cyceron, U1077, NIMH, Caen, 14000, France.

Jean-Jacques Parienti (JJ)

Department de Biostatistiques, CHU de Caen, Université Caen Normandie, INSERM U1311 DYNAMICURE, Caen, 14000, France.

Shailendra Segobin (S)

Université de Caen Normandie, Inserm, EPHE, PSL Université Paris, CHU de Caen, GIP Cyceron, U1077, NIMH, Caen, 14000, France.

Armelle Viard (A)

Université de Caen Normandie, Inserm, EPHE, PSL Université Paris, CHU de Caen, GIP Cyceron, U1077, NIMH, Caen, 14000, France.

Gisèle Apter (G)

Département de psychiatrie pôle mère-enfant, Centre hospitalier du Havre, Université Rouen Normandie, Le Havre, 76600, France.

Priscille Gerardin (P)

Département de psychiatrie de l'enfant et de l'adolescent, CHU de Rouen, Université Rouen Normandie, Rouen, 76031, France.
Centre de Recherches sur les Fonctionnements et Dysfonctionnements Psychologiques (CRFDP, EA 7475), Mont Saint Aignan, 76821, France.

Bérengère Guillery (B)

Université de Caen Normandie, Inserm, EPHE, PSL Université Paris, CHU de Caen, GIP Cyceron, U1077, NIMH, Caen, 14000, France.

Fabian Guénolé (F)

Université de Caen Normandie, Inserm, EPHE, PSL Université Paris, CHU de Caen, GIP Cyceron, U1077, NIMH, Caen, 14000, France. guenole-f@chu-caen.fr.
Service de Psychiatrie de l'Enfant et de l'Adolescent du CHU de Caen Normandie, CHU Caen Normandie, 14 Avenue Clemenceau, Caen Cedex, 14033, France. guenole-f@chu-caen.fr.

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Classifications MeSH

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