Curcumin/pEGCG-encapsulated nanoparticles enhance spinal cord injury recovery by regulating CD74 to alleviate oxidative stress and inflammation.
Animals
Curcumin
/ pharmacology
Spinal Cord Injuries
/ drug therapy
Oxidative Stress
/ drug effects
Mice
Nanoparticles
/ chemistry
Inflammation
/ drug therapy
Catechin
/ pharmacology
Mice, Inbred C57BL
Hyaluronic Acid
/ chemistry
Reactive Oxygen Species
/ metabolism
Microglia
/ drug effects
Polyethylene Glycols
/ chemistry
Female
Recovery of Function
/ drug effects
CD74
Curcumin
Mice
ROS
SCI
Journal
Journal of nanobiotechnology
ISSN: 1477-3155
Titre abrégé: J Nanobiotechnology
Pays: England
ID NLM: 101152208
Informations de publication
Date de publication:
24 Oct 2024
24 Oct 2024
Historique:
received:
28
07
2024
accepted:
09
10
2024
medline:
24
10
2024
pubmed:
24
10
2024
entrez:
24
10
2024
Statut:
epublish
Résumé
Spinal cord injury (SCI) often accompanies impairment of motor function, yet there is currently no highly effective treatment method specifically for this condition. Oxidative stress and inflammation are pivotal factors contributing to severe neurological deficits after SCI. In this study, a type of curcumin (Cur) nanoparticle (HA-CurNPs) was developed to address this challenge by alleviating oxidative stress and inflammation. Through non-covalent interactions, curcumin (Cur) and poly (-)-epigallocatechin-3-gallate (pEGCG) are co-encapsulated within hyaluronic acid (HA), resulting in nanoparticles termed HA-CurNPs. These nanoparticles gradually release curcumin and pEGCG at the SCI site. The released pEGCG and curcumin not only scavenge reactive oxygen species (ROS) and prevents apoptosis, thereby improving the neuronal microenvironment, but also regulate CD74 to promote microglial polarization toward an M2 phenotype, and inhibits M1 polarization, thereby suppressing the inflammatory response and fostering neuronal regeneration. Moreover, in vivo experiments on SCI mice demonstrate that HA-CurNPs effectively protect neuronal cells and myelin, reduce glial scar formation, thereby facilitating the repair of damaged spinal cord tissues, restoring electrical signaling at the injury site, and improving motor functions. Overall, this study demonstrates that HA-CurNPs significantly reduce oxidative stress and inflammation following SCI, markedly improving motor function in SCI mice. This provides a promising therapeutic approach for the treatment of SCI.
Identifiants
pubmed: 39443923
doi: 10.1186/s12951-024-02916-4
pii: 10.1186/s12951-024-02916-4
doi:
Substances chimiques
Curcumin
IT942ZTH98
Catechin
8R1V1STN48
epigallocatechin gallate
BQM438CTEL
Hyaluronic Acid
9004-61-9
Reactive Oxygen Species
0
Polyethylene Glycols
3WJQ0SDW1A
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
653Subventions
Organisme : The Open Fund of Guangdong Provincial Key Laboratory of Laboratory of Spine and Spinal Cord Reconstruction
ID : 2023B121203001
Organisme : National Natural Science Foundation of China
ID : Nos.32170977
Organisme : National Natural Science Foundation of China
ID : Nos. 82102314
Organisme : Natural Science Foundation of Guangdong Province
ID : Nos.2022A1515012306
Organisme : Natural Science Foundation of Guangdong Province
ID : Nos. 2022A1515010438
Organisme : Clinical Frontier Technology Program of the First Affiliated Hospital of Jinan University
ID : Nos. JNU1AF-CFTP- 2022- a01206
Organisme : Guangzhou Science and TechnologyPlan Projec
ID : 2023A03J1024
Organisme : Guangzhou Science and TechnologyPlan Project
ID : 202201020018
Organisme : Guangzhou Science and TechnologyPlan Project
ID : 2023A04J1284
Organisme : Young Talent Support Project of Guangzhou Association for Science and Technology
ID : QT2024-39
Informations de copyright
© 2024. The Author(s).
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