MHC Class II Supertypes Affect Survival and Lifetime Reproductive Success in a Migratory Songbird.
MHC supertypes
balancing selection
fluctuating selection
lifetime reproductive success
major histocompatibility complex
mark–capture–recapture models
pied flycatchers
survival
Journal
Molecular ecology
ISSN: 1365-294X
Titre abrégé: Mol Ecol
Pays: England
ID NLM: 9214478
Informations de publication
Date de publication:
24 Oct 2024
24 Oct 2024
Historique:
received:
06
04
2022
accepted:
27
08
2024
medline:
24
10
2024
pubmed:
24
10
2024
entrez:
24
10
2024
Statut:
aheadofprint
Résumé
The major histocompatibility complex (MHC) plays a critical role in the immune response against pathogens. Its high polymorphism is thought to be mainly the consequence of host-pathogen co-evolution, but elucidating the mechanism(s) driving MHC evolution remains challenging for natural populations. We investigated the diversity of MHC class II genes in a wild population of pied flycatchers Ficedula hypoleuca and tested its associations with two key components of individual fitness: lifetime reproductive success and survival. Among 180 breeding adults in our study population, we found 182 unique MHC class II exon 2 alleles. The alleles showed a strong signal of positive selection and grouped into nine functional supertypes based on physicochemical properties at the inferred antigen-binding sites. Three supertypes were found in > 98% of the sampled individuals, indicating that they are nearly fixed in the population. We found no rare supertypes in the population, as all supertypes were present in > 70% of individuals. Three supertypes were related to different components of individual fitness: two were associated with lower offspring production over time, while the third was positively associated with survival. Overall, the substantial allelic and functional diversity and the relationship between specific supertypes and fitness are in accordance with the notion that balancing selection maintains MHC class II diversity in the study population, possibly with fluctuating selection as the underlying mechanism. The absence of rare supertypes in the population suggests that the balancing selection is not driven by rare-allele advantage.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e17554Subventions
Organisme : Ministerio de Ciencia e Innovación-Agencia Estatal de Investigación, MCIN/AEI
ID : PID2022-141763NA-I00
Organisme : Ministerio de Ciencia e Innovación-Agencia Estatal de Investigación, MCIN/AEI
ID : RYC2021-033977-I
Organisme : Autonomous Community of Madrid (CAM)
ID : Talent Attraction fellowship- 2022-T1_AMB-24025
Organisme : Ministerio de Ciencia e Innovación
ID : CGL2006-07481/BOS
Organisme : Ministerio de Ciencia e Innovación
ID : CGL2014-55969-P
Organisme : Ministerio de Ciencia e Innovación
ID : CGL2015-70639-P
Organisme : Ministerio de Ciencia e Innovación
ID : PAC05-006-2
Informations de copyright
© 2024 The Author(s). Molecular Ecology published by John Wiley & Sons Ltd.
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