Humoral and cellular response to the third COVID-19 vaccination in patients with inborn errors of immunity or mannose-binding lectin deficiency : A prospective controlled open-label trial.

Common variable immunodeficiency Hypogammaglobulinemia Immunosuppression Mannose-binding lectin Primary immunodeficiency disorder

Journal

Wiener klinische Wochenschrift
ISSN: 1613-7671
Titre abrégé: Wien Klin Wochenschr
Pays: Austria
ID NLM: 21620870R

Informations de publication

Date de publication:
24 Oct 2024
Historique:
received: 07 07 2024
accepted: 23 09 2024
medline: 24 10 2024
pubmed: 24 10 2024
entrez: 24 10 2024
Statut: aheadofprint

Résumé

Impaired immune response to COVID-19 (coronavirus disease 2019) vaccination has been reported in patients with inborn errors of immunity (IEI). Repetitive vaccinations are recommended for this vulnerable group. Due to the high diversity within IEI patients, additional safety and immunogenicity data are needed to better understand these aspects especially in less common immunodeficiency syndromes. In this prospective open-label clinical trial, we assessed the humoral immune response and the T‑cell response in patients with IEI or severe MBL (mannose-binding lectin) deficiency (IEI/MBLdef) after three vaccinations. A total of 16 patients and 16 matched healthy controls (HC) with suboptimal humoral response defined by anti-SARS-CoV‑2 RBD (severe acute respiratory syndrome coronavirus type 2 receptor binding domain) antibodies below 1500 BAU/ml (binding antibody units per ml) after the second COVID-19 vaccination were enrolled in this study and qualified for a third mRNA vaccine dose. After 4 weeks following vaccination, 100% of HC and 75% of IEI/MBLdef patients exhibited anti-SARS-CoV‑2 RBD antibodies > 1500 BAU/ml, although the difference was not statistically significant (75% vs. 100%; p = 0.109). Although post-vaccination IEI/MBLdef patients demonstrated significantly increased anti-SARS-CoV‑2 RBD antibodies and neutralizing antibodies compared to baseline, these responses were significantly lower in IEI/MBLdef patients compared to HCs. Notably, the third vaccination augmented the cellular immune response to both wild-type and omicron peptide stimulation. No serious adverse events were reported within the 4‑week follow-up period and, importantly, vaccination had little to no effect on the long-term disease activity and fatigue. This trial strongly supports the recommendation of repeated COVID-19 vaccinations for patients suffering from immunodeficiencies, especially when they exhibit an initially limited response to the vaccine.

Identifiants

pubmed: 39446203
doi: 10.1007/s00508-024-02459-6
pii: 10.1007/s00508-024-02459-6
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Matthias G Vossen (MG)

Division of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Comprehensive Center for Infection Medicine, Medical University of Vienna, Austria (CCIM), Vienna, Austria.

Felix Kartnig (F)

Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria.

Daniel Mrak (D)

Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria.

Elisabeth Simader (E)

Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria.

Karin Stiasny (K)

Center for Virology, Medical University of Vienna, Vienna, Austria.
Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria.

Renate Kain (R)

Medical University of Vienna, Clinical Institute for Pathology, Vienna, Austria.
Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria.

Thomas Perkmann (T)

Clinical Institute for Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria.

Helmuth Haslacher (H)

Clinical Institute for Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria.

Judith H Aberle (JH)

Center for Virology, Medical University of Vienna, Vienna, Austria.
Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria.

Leonhard X Heinz (LX)

Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria.

Daniela Sieghart (D)

Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria.

Heinz Burgmann (H)

Division of Infectious Diseases and Tropical Medicine, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Comprehensive Center for Infection Medicine, Medical University of Vienna, Austria (CCIM), Vienna, Austria.

Daniel Aletaha (D)

Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria.

Clemens Scheinecker (C)

Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria.

Michael Bonelli (M)

Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria.

Lisa Göschl (L)

Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria. lisa.goeschl@meduniwien.ac.at.
Comprehensive Center for Inflammation and Immunity, Medical University of Vienna, Austria (CCII), Vienna, Austria. lisa.goeschl@meduniwien.ac.at.

Classifications MeSH