Hypothalamic regulation of hippocampal CA1 interneurons by the supramammillary nucleus.
CA1
CA2
CP: Neuroscience
dentate gyrus
hippocampus
interneurons
neurogliaform cell
parvalbumin
stratum lacunosum-moleculare
supramammillary nucleus
vasoactive intestinal peptide
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
23 Oct 2024
23 Oct 2024
Historique:
received:
15
03
2024
revised:
14
09
2024
accepted:
05
10
2024
medline:
25
10
2024
pubmed:
25
10
2024
entrez:
24
10
2024
Statut:
aheadofprint
Résumé
The hypothalamic supramammillary nucleus (SuM) projects heavily to the hippocampus to regulate hippocampal activity and plasticity. Although the projections from the SuM to the dentate gyrus (DG) and CA2 have been extensively studied, whether the SuM projects to CA1, the main hippocampal output region, is unclear. Here, we report a glutamatergic pathway from the SuM that selectively excites CA1 interneurons in the border between the stratum radiatum (SR) and the stratum lacunosum-moleculare (SLM). We find that the SuM projects selectively to a narrow band in the CA1 SR/SLM and monosynaptically excites SR/SLM interneurons, including vasoactive intestinal peptide-expressing (VIP
Identifiants
pubmed: 39446584
pii: S2211-1247(24)01249-X
doi: 10.1016/j.celrep.2024.114898
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114898Informations de copyright
Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.