A ubiquitous mobile genetic element changes the antagonistic weaponry of a human gut symbiont.

Humans Gastrointestinal Microbiome Type VI Secretion Systems / genetics Bacteroides fragilis / genetics Symbiosis Interspersed Repetitive Sequences Gene Transfer, Horizontal Conjugation, Genetic Genetic Fitness Genome, Bacterial

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
25 Oct 2024
Historique:
medline: 25 10 2024
pubmed: 25 10 2024
entrez: 24 10 2024
Statut: ppublish

Résumé

DNA transfer is ubiquitous in the human gut microbiota, especially among species of the order Bacteroidales. In silico analyses have revealed hundreds of mobile genetic elements shared between these species, yet little is known about the phenotypes they encode, their effects on fitness, or pleiotropic consequences for the recipient's genome. In this work, we show that acquisition of a ubiquitous integrative conjugative element (ICE) encoding a type VI secretion system (T6SS) shuts down the native T6SS of

Identifiants

DOI: 10.1126/science.adj9504 PMID: 39446952
pubmed: 39446952
doi: 10.1126/science.adj9504
doi:

Substances chimiques

Type VI Secretion Systems 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

414-420

Auteurs

Madeline L Sheahan (ML)

Duchossois Family Institute, University of Chicago, Chicago, IL, USA.
Department of Microbiology, University of Chicago, Chicago, IL, USA.
ORCID: 0009-0008-3152-8381

Katia Flores (K)

Duchossois Family Institute, University of Chicago, Chicago, IL, USA.
Department of Microbiology, University of Chicago, Chicago, IL, USA.
ORCID: 0009-0006-4410-1462

Michael J Coyne (MJ)

Duchossois Family Institute, University of Chicago, Chicago, IL, USA.
Department of Microbiology, University of Chicago, Chicago, IL, USA.
Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Leonor García-Bayona (L)

Duchossois Family Institute, University of Chicago, Chicago, IL, USA.
Department of Microbiology, University of Chicago, Chicago, IL, USA.
Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0003-3176-4225

Maria Chatzidaki-Livanis (M)

Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Andrea Q Holst (AQ)

Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
National Food Institute, Technical University of Denmark, Lyngby, Denmark.
ORCID: 0000-0003-2415-316X

Rita C Smith (RC)

Duchossois Family Institute, University of Chicago, Chicago, IL, USA.
ORCID: 0000-0002-7546-5019

Anitha Sundararajan (A)

Duchossois Family Institute, University of Chicago, Chicago, IL, USA.

Blanca Barquera (B)

Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.
Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY, USA.
Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.
ORCID: 0000-0003-0708-3438

Laurie E Comstock (LE)

Duchossois Family Institute, University of Chicago, Chicago, IL, USA.
Department of Microbiology, University of Chicago, Chicago, IL, USA.
Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
ORCID: 0009-0002-6368-8351

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A ubiquitous mobile genetic element changes...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › A ubiquitous mobile genetic element changes...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Systèmes de translocation des protéines › Systèmes bactériens de sécrétion › Systèmes de sécrétion de type VI › A ubiquitous mobile genetic element changes...
questionsmedicales.fr › Bactéries › Bactéries à Gram négatif › Bactéries anaérobies à Gram négatif › Bâtonnets à Gram négatif anaérobies droits, incurvés et spiralés › Bacteroidaceae › Bacteroides › Bacteroides fragilis › A ubiquitous mobile genetic element changes...
questionsmedicales.fr › Phénomènes biologiques › Symbiose › A ubiquitous mobile genetic element changes...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Séquences répétées dispersées › A ubiquitous mobile genetic element changes...
questionsmedicales.fr › Phénomènes génétiques › Recombinaison génétique › Transfert horizontal de gène › A ubiquitous mobile genetic element changes...
questionsmedicales.fr › Phénomènes génétiques › Recombinaison génétique › Conjugaison génétique › A ubiquitous mobile genetic element changes...
questionsmedicales.fr › Phénomènes génétiques › Aptitude génétique › A ubiquitous mobile genetic element changes...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Génome microbien › Génome bactérien › A ubiquitous mobile genetic element changes...