Decomposition of mixed DMPC-aescin vesicles to bicelles is linked to the lipid's main phase transition: A direct evidence by using chain-deuterated lipid.

This work investigates the conversion of bicelles into larger sheets or closed vesicles upon dilution and temperature increase for a system composed of the phospholipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and the saponin aescin. Due to its peculiar amphiphilic character, aescin is able to decompose DMPC bilayers into smaller, rim-stabilized bicelles. Aspects of the transition process are analyzed in an aescin content- and temperature-dependent manner by photon correlation spectroscopy (PCS), turbidimetry and small-angle neutron scattering (SANS). Both the conversion of bicelles into vesicles induced by temperature increase and the decomposition process upon cooling are presumably related to the main phase transition temperature T

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Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.