Associations between maternal per- and polyfluoroalkyl substances exposure and lipid levels in maternal and cord blood: The Japan Environment and Children's Study.
lipid metabolism
lipids
maternal exposure
per- and polyfluoroalkyl substances
Journal
Environmental research
ISSN: 1096-0953
Titre abrégé: Environ Res
Pays: Netherlands
ID NLM: 0147621
Informations de publication
Date de publication:
22 Oct 2024
22 Oct 2024
Historique:
received:
19
07
2024
revised:
18
10
2024
accepted:
21
10
2024
medline:
25
10
2024
pubmed:
25
10
2024
entrez:
24
10
2024
Statut:
aheadofprint
Résumé
Despite numerous studies, the associations between per- and polyfluoroalkyl substances (PFAS) exposure and various lipid levels in pregnant women remain ambiguous, especially concerning the association with cord blood lipids. This analysis included 20,960 pregnant women enrolled in the Japan Environment and Children's Study, recruited between 2011 and 2014. Non-fasting plasma samples collected before 22 weeks of gestation were examined for PFAS concentrations. Additionally, non-fasting serum samples collected before, at and after 22 weeks of gestation, at birth, and from cord blood were used to measure total cholesterol (TC) and triglycerides (TG). Linear regression models were applied to quantify the association between each PFAS and various lipid metrics. Among the 28 PFAS analyzed, 7 were quantifiable in more than 80% of participants. Of these, 6 PFAS showed positive associations with TC in maternal blood before 22 weeks of gestation, a trend that remained mostly consistent for maternal blood samples in later stages. However, no associations were found with TC levels in cord blood. Regarding TG, 3 PFAS demonstrated a negative association with TG levels in maternal blood before 22 weeks of gestation, with these relationships generally persisting in later stages, while 4 PFAS were positively associated with TG in cord blood. In summary, this study identified associations between PFAS concentrations in maternal blood and lipid levels in both maternal and cord blood, with differing patterns observed between the two.
Identifiants
pubmed: 39448010
pii: S0013-9351(24)02124-8
doi: 10.1016/j.envres.2024.120217
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
120217Investigateurs
Michihiro Kamijima
(M)
Shin Yamazaki
(S)
Maki Fukami
(M)
Reiko Kishi
(R)
Chiharu Ota
(C)
Koichi Hashimoto
(K)
Chisato Mori
(C)
Shuichi Ito
(S)
Ryoji Shinohara
(R)
Hidekuni Inadera
(H)
Takeo Nakayama
(T)
Ryo Kawasaki
(R)
Yasuhiro Takeshima
(Y)
Seiji Kageyama
(S)
Narufumi Suganuma
(N)
Shoichi Ohga
(S)
Takahiko Katoh
(T)
Informations de copyright
Copyright © 2024. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest ☒ The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. ☐ The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: