Efficacy of gabapentin and pregabalin for treatment of post refractive surgery pain: a systematic review and meta-analysis.
Gabapentin
Laser epithelial keratomileusis
Laser-assisted in situ keratomileusis
Meta-analysis
Pain control
Photo refractive keratectomy
Post refractive surgery
Pregabalin
Systematic review
Journal
International ophthalmology
ISSN: 1573-2630
Titre abrégé: Int Ophthalmol
Pays: Netherlands
ID NLM: 7904294
Informations de publication
Date de publication:
24 Oct 2024
24 Oct 2024
Historique:
received:
10
05
2024
accepted:
28
08
2024
medline:
25
10
2024
pubmed:
25
10
2024
entrez:
24
10
2024
Statut:
epublish
Résumé
For ophthalmic patients, eye discomfort is a major problem that requires efficient pain treatment techniques. Pregabalin and gabapentin have surfaced as viable treatments for post-refractive surgery pain. To manage pain after refractive surgery, gabapentin and pregabalin were evaluated in this systematic review and meta-analysis. A thorough search of databases including PubMed, Embase, Cochrane Library, and CINAHL was performed until March 2024. Inclusion criteria were randomized controlled trials assessing pregabalin and/or gabapentin's effectiveness in treating pain post-PRK, LASIK, and LASEK surgeries. Six studies met inclusion criteria, comprising a total of 391 patients undergoing various corneal surgeries. The meta-analysis revealed that pregabalin was significantly more effective than placebo in reducing pain on the first and second postoperative days (SMD day 1: -0.32, 95% CI -0.54, -0.09; SMD day 2: -0.55, 95% CI -0.85, -0.25), while gabapentin showed significant pain reduction on the second day only (SMD day 2: -0.42, 95% CI -0.71, -0.13). Combined analysis for both medications showed significant pain reduction on the first- and second-days post-surgery. No significant increase in adverse events was associated with either medication. Publication bias was minimal except for a slight asymmetry noted on day 1 effectiveness. Pregabalin and gabapentin are effective in reducing postoperative pain following refractive surgeries, with pregabalin showing a greater effect. Both medications are safe, with no significant increase in adverse events. Further research with standardized methodologies and long-term follow-up is recommended to optimize postoperative pain management in ocular surgeries.
Identifiants
pubmed: 39448432
doi: 10.1007/s10792-024-03300-9
pii: 10.1007/s10792-024-03300-9
doi:
Substances chimiques
Pregabalin
55JG375S6M
Gabapentin
6CW7F3G59X
Analgesics
0
Types de publication
Journal Article
Systematic Review
Meta-Analysis
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
409Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature B.V.
Références
Pflipsen M, Massaquoi M, Wolf S (2016) Evaluation of the painful eye. Am Fam Physician 93(12):991–998
pubmed: 27304768
Galor A, Levitt RC, Felix ER, Martin ER, Sarantopoulos CD (2015) Neuropathic ocular pain: an important yet underevaluated feature of dry eye. Eye 29(3):301–312. https://doi.org/10.1038/eye.2014.263
doi: 10.1038/eye.2014.263
pubmed: 25376119
Borsook D, Kussman BD, George E, Becerra LR, Burke DW (2013) Surgically induced neuropathic pain: understanding the perioperative process. Ann Surg 257(3):403–412. https://doi.org/10.1097/SLA.0b013e3182701a7b
doi: 10.1097/SLA.0b013e3182701a7b
pubmed: 23059501
Ellis A, Bennett DLH (2013) Neuroinflammation and the generation of neuropathic pain. Br J Anaesth 111(1):26–37. https://doi.org/10.1093/bja/aet128
doi: 10.1093/bja/aet128
pubmed: 23794642
Mitsikostas DD, Moka E, Orrillo E et al (2022) Neuropathic pain in neurologic disorders: a narrative review. Cureus 14(2):e22419. https://doi.org/10.7759/cureus.22419
doi: 10.7759/cureus.22419
pubmed: 35345699
pmcid: 8942164
Jacobs DS (2017) Diagnosis and treatment of ocular pain: the ophthalmologist’s perspective. Curr Ophthalmol Rep 5(4):271–275. https://doi.org/10.1007/s40135-017-0152-1
doi: 10.1007/s40135-017-0152-1
pubmed: 29226029
pmcid: 5711963
Chincholkar M (2020) Gabapentinoids: pharmacokinetics, pharmacodynamics and considerations for clinical practice. Br J Pain 14(2):104–114. https://doi.org/10.1177/2049463720912496
doi: 10.1177/2049463720912496
pubmed: 32537149
pmcid: 7265598
Peckham AM, Evoy KE, Ochs L, Covvey JR (2018) Gabapentin for off-label use: evidence-based or cause for concern? Subst Abuse 12:1178221818801311. https://doi.org/10.1177/1178221818801311
doi: 10.1177/1178221818801311
pubmed: 30262984
pmcid: 6153543
Hamer AM, Haxby DG, McFarland BH, Ketchum K (2002) Gabapentin use in a managed medicaid population. J Manag Care Pharm 8(4):266–271. https://doi.org/10.18553/jmcp.2002.8.4.266
doi: 10.18553/jmcp.2002.8.4.266
pubmed: 14613419
Fukada C, Kohler JC, Boon H, Austin Z, Krahn M (2012) Prescribing gabapentin off label: perspectives from psychiatry, pain and neurology specialists. Can Pharm J (Ott) 145(6):280-284.e1. https://doi.org/10.3821/145.6.cpj280
doi: 10.3821/145.6.cpj280
pubmed: 23509590
Goodman CW, Brett AS (2019) Gabapentinoids for pain: potential unintended consequences. Am Fam Physician 100(11):672–675
pubmed: 31790179
Rullán M, Bulilete O, Leiva A et al (2017) Efficacy of gabapentin for prevention of postherpetic neuralgia: study protocol for a randomized controlled clinical trial. Trials 18(1):24. https://doi.org/10.1186/s13063-016-1729-y
doi: 10.1186/s13063-016-1729-y
pubmed: 28088231
pmcid: 5237496
Bulilete O, Leiva A, Rullán M, Roca A, Llobera J (2019) Efficacy of gabapentin for the prevention of postherpetic neuralgia in patients with acute herpes zoster: a double blind, randomized controlled trial. PLoS ONE 14(6):e0217335. https://doi.org/10.1371/journal.pone.0217335
doi: 10.1371/journal.pone.0217335
pubmed: 31166976
pmcid: 6550400
Yamauchi T, Kaneko S, Yagi K, Sase S (2006) Treatment of partial seizures with gabapentin: double-blind, placebo-controlled, parallel-group study. Psychiatry Clin Neurosci 60(4):507–515. https://doi.org/10.1111/j.1440-1819.2006.01553.x
doi: 10.1111/j.1440-1819.2006.01553.x
pubmed: 16884455
Kume A (2014) Gabapentin enacarbil for the treatment of moderate to severe primary restless legs syndrome (Willis-Ekbom disease): 600 or 1200 mg dose? Neuropsychiatr Dis Treat 10:249–262. https://doi.org/10.2147/ndt.S30160
doi: 10.2147/ndt.S30160
pubmed: 24523590
pmcid: 3921090
Kneib CJ, Sibbett SH, Carrougher GJ, Muffley LA, Gibran NS, Mandell SP (2019) The effects of early neuropathic pain control with gabapentin on long-term chronic pain and itch in burn patients. J Burn Care Res 40(4):457–463. https://doi.org/10.1093/jbcr/irz036
doi: 10.1093/jbcr/irz036
pubmed: 30893433
Ben-Menachem E (2004) Pregabalin pharmacology and its relevance to clinical practice. Epilepsia 45(Suppl 6):13–18. https://doi.org/10.1111/j.0013-9580.2004.455003.x
doi: 10.1111/j.0013-9580.2004.455003.x
pubmed: 15315511
Alles SRA, Cain SM, Snutch TP (2020) Pregabalin as a pain therapeutic: beyond calcium channels. Front Cell Neurosci 14:83. https://doi.org/10.3389/fncel.2020.00083
doi: 10.3389/fncel.2020.00083
pubmed: 32351366
pmcid: 7174704
Goa KL, Gabapentin SEM (1993) A review of its pharmacological properties and clinical potential in epilepsy. Drugs 46(3):409–427. https://doi.org/10.2165/00003495-199346030-00007
doi: 10.2165/00003495-199346030-00007
pubmed: 7693432
Alghamdi K, Lysecki D (2023) Role of gabapentin in reducing the need for high-risk medications in patients with stable severe neurological impairment. J Taibah Univ Med Sci 18(1):170–174. https://doi.org/10.1016/j.jtumed.2022.07.006
doi: 10.1016/j.jtumed.2022.07.006
pubmed: 36398026
Patel R, Dickenson AH (2016) Mechanisms of the gabapentinoids and α 2 δ-1 calcium channel subunit in neuropathic pain. Pharmacol Res Perspect 4(2):e00205. https://doi.org/10.1002/prp2.205
doi: 10.1002/prp2.205
pubmed: 27069626
pmcid: 4804325
Li Z, Taylor CP, Weber M et al (2011) Pregabalin is a potent and selective ligand for α(2)δ-1 and α(2)δ-2 calcium channel subunits. Eur J Pharmacol 667(1–3):80–90. https://doi.org/10.1016/j.ejphar.2011.05.054
doi: 10.1016/j.ejphar.2011.05.054
pubmed: 21651903
Takahashi DK, Jin S, Prince DA (2018) Gabapentin prevents progressive increases in excitatory connectivity and epileptogenesis following neocortical trauma. Cereb Cortex 28(8):2725–2740. https://doi.org/10.1093/cercor/bhx152
doi: 10.1093/cercor/bhx152
pubmed: 28981586
Rossi A, Murta V, Auzmendi J, Ramos AJ (2017) Early gabapentin treatment during the latency period increases convulsive threshold, reduces microglial activation and macrophage infiltration in the lithium-pilocarpine model of epilepsy. Pharmaceuticals (Basel) 10(4):93. https://doi.org/10.3390/ph10040093
doi: 10.3390/ph10040093
pubmed: 29182533
Foldvary-Schaefer N, De Leon SI, Karafa M, Mascha E, Dinner D, Morris HH (2002) Gabapentin increases slow-wave sleep in normal adults. Epilepsia 43(12):1493–1497. https://doi.org/10.1046/j.1528-1157.2002.21002.x
doi: 10.1046/j.1528-1157.2002.21002.x
pubmed: 12460250
Wilson SE (2020) Biology of keratorefractive surgery- PRK, PTK, LASIK, SMILE, inlays and other refractive procedures. Exp Eye Res 198:108136. https://doi.org/10.1016/j.exer.2020.108136
doi: 10.1016/j.exer.2020.108136
pubmed: 32653492
pmcid: 7508965
Alio JL, Javaloy J (2013) Corneal inflammation following corneal photoablative refractive surgery with excimer laser. Surv Ophthalmol 58(1):11–25. https://doi.org/10.1016/j.survophthal.2012.04.005
doi: 10.1016/j.survophthal.2012.04.005
pubmed: 23217585
Spadea L, Giovannetti F (2019) Main complications of photorefractive keratectomy and their management. Clin Ophthalmol 13:2305–2315. https://doi.org/10.2147/opth.S233125
doi: 10.2147/opth.S233125
pubmed: 31819355
pmcid: 6885542
Kahuam-López N, Navas A, Castillo-Salgado C, Graue-Hernandez EO, Jimenez-Corona A, Ibarra A (2020) Laser-assisted in-situ keratomileusis (LASIK) with a mechanical microkeratome compared to LASIK with a femtosecond laser for LASIK in adults with myopia or myopic astigmatism. Cochrane Database Syst Rev 4(4):Cd012946. https://doi.org/10.1002/14651858.CD012946.pub2
doi: 10.1002/14651858.CD012946.pub2
pubmed: 32255519
Chang JY, Lin PY, Hsu CC, Liu CJ (2022) Comparison of clinical outcomes of LASIK, Trans-PRK, and SMILE for correction of myopia. J Chin Med Assoc 85(2):145–151. https://doi.org/10.1097/jcma.0000000000000674
doi: 10.1097/jcma.0000000000000674
pubmed: 34861667
Kuryan J, Cheema A, Chuck RS (2017) Laser-assisted subepithelial keratectomy (LASEK) versus laser-assisted in-situ keratomileusis (LASIK) for correcting myopia. Cochrane Database Syst Rev 2(2):Cd011080. https://doi.org/10.1002/14651858.CD011080.pub2
doi: 10.1002/14651858.CD011080.pub2
pubmed: 28197998
Liu M, Shi W, Liu X, Li N, Chen T, Gao H (2021) Postoperative corneal biomechanics and influencing factors during femtosecond-assisted laser in situ keratomileusis (FS-LASIK) and laser-assisted subepithelial keratomileusis (LASEK) for high myopia. Lasers Med Sci 36(8):1709–1717. https://doi.org/10.1007/s10103-021-03320-2
doi: 10.1007/s10103-021-03320-2
pubmed: 33891212
Azar DT, Chang JH, Han KY (2012) Wound healing after keratorefractive surgery: review of biological and optical considerations. Cornea 31(Suppl 1):S9–S19. https://doi.org/10.1097/ICO.0b013e31826ab0a7
doi: 10.1097/ICO.0b013e31826ab0a7
pubmed: 23038040
pmcid: 3682490
Galor A, Patel S, Small LR et al (2019) Pregabalin failed to prevent dry eye symptoms after laser-assisted in situ keratomileusis (LASIK) in a randomized pilot study. J Clin Med 8(9):1355. https://doi.org/10.3390/jcm8091355
doi: 10.3390/jcm8091355
pubmed: 31480601
pmcid: 6780750
Shen X, Chen X, He Y, Xu H, Zhu J (2023) Efficacy and safety of pregabalin in eye pain: a systematic review. Medicine (Baltimore) 102(6):e32875. https://doi.org/10.1097/md.0000000000032875
doi: 10.1097/md.0000000000032875
pubmed: 36820573
Liberati A, Altman DG, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339:b2700. https://doi.org/10.1136/bmj.b2700
doi: 10.1136/bmj.b2700
pubmed: 19622552
pmcid: 2714672
Cumpston M, Li T, Page MJ, et al (2019) Updated guidance for trusted systematic reviews: a new edition of the cochrane handbook for systematic reviews of interventions. Cochrane Database Syst Rev 10(10): Ed000142 https://doi.org/10.1002/14651858.Ed000142
Sterne JAC, Savović J, Page MJ et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:l4898. https://doi.org/10.1136/bmj.l4898
doi: 10.1136/bmj.l4898
pubmed: 31462531
Pakravan M, Roshani M, Yazdani S, Faramazi A, Yaseri M (2012) Pregabalin and gabapentin for post-photorefractive keratectomy pain: a randomized controlled trial. Eur J Ophthalmol 22(Suppl 7):S106–S113. https://doi.org/10.5301/ejo.5000143
doi: 10.5301/ejo.5000143
pubmed: 22577038
Kuhnle MD, Ryan DS, Coe CD et al (2011) Oral gabapentin for photorefractive keratectomy pain. J Cataract Refract Surg 37(2):364–369. https://doi.org/10.1016/j.jcrs.2010.08.041
doi: 10.1016/j.jcrs.2010.08.041
pubmed: 21241922
Lichtinger A, Purcell TL, Schanzlin DJ, Chayet AS (2011) Gabapentin for postoperative pain after photorefractive keratectomy: a prospective, randomized, double-blind, placebo-controlled trial. J Refract Surg 27(8):613–617. https://doi.org/10.3928/1081597x-20110210-01
doi: 10.3928/1081597x-20110210-01
pubmed: 21366172
Paik DW, Lim DH, Chung TY (2022) Effects of taking pregabalin (Lyrica) on the severity of dry eye, corneal sensitivity and pain after laser epithelial keratomileusis surgery. Br J Ophthalmol 106(4):474–479. https://doi.org/10.1136/bjophthalmol-2020-317570
doi: 10.1136/bjophthalmol-2020-317570
pubmed: 33303426
Meek JM, Rosbolt MB, Taylor KR, Fusco EA, Panday VA, Reilly CD (2014) Pregabalin versus placebo in postoperative pain relief of patients’ status post photorefractive keratectomy: a double-masked, randomized, prospective study. J Ocul Pharmacol Ther 30(7):527–532. https://doi.org/10.1089/jop.2013.0208
doi: 10.1089/jop.2013.0208
pubmed: 24914779
Small LR, Galor A, Felix ER, Horn DB, Levitt RC, Sarantopoulos CD (2020) Oral gabapentinoids and nerve blocks for the treatment of chronic ocular pain. Eye Contact Lens 46(3):174–181. https://doi.org/10.1097/icl.0000000000000630
doi: 10.1097/icl.0000000000000630
pubmed: 31206369
Fiore DC, Pasternak AV, Radwan RM (2010) Pain in the quiet (not red) eye. Am Fam Physician 82(1):69–73
pubmed: 20590074
Derry S, Bell RF, Straube S, Wiffen PJ, Aldington D, Moore RA (2019) Pregabalin for neuropathic pain in adults. Cochrane Database Syst Rev 1(1):Cd007076. https://doi.org/10.1002/14651858.CD007076.pub3
doi: 10.1002/14651858.CD007076.pub3
pubmed: 30673120
Reddi D (2016) Preventing chronic postoperative pain. Anaesthesia 71(Suppl 1):64–71. https://doi.org/10.1111/anae.13306
doi: 10.1111/anae.13306
pubmed: 26620149
Guay DR (2005) Pregabalin in neuropathic pain: a more “pharmaceutically elegant” gabapentin? Am J Geriatr Pharmacother 3(4):274–287
doi: 10.1016/j.amjopharm.2005.12.008
pubmed: 16503325
McKeage K, Keam SJ (2009) Pregabalin: in the treatment of postherpetic neuralgia. Drugs Aging 26(10):883–892. https://doi.org/10.2165/11203750-000000000-00000
doi: 10.2165/11203750-000000000-00000
pubmed: 19761281
Robertson K, Marshman LAG, Plummer D, Downs E (2019) Effect of gabapentin vs pregabalin on pain intensity in adults with chronic sciatica: a randomized clinical trial. JAMA Neurol 76(1):28–34. https://doi.org/10.1001/jamaneurol.2018.3077
doi: 10.1001/jamaneurol.2018.3077
pubmed: 30326006
Wen YR, Tan PH, Cheng JK, Liu YC, Ji RR (2011) Microglia: a promising target for treating neuropathic and postoperative pain, and morphine tolerance. J Formos Med Assoc 110(8):487–494. https://doi.org/10.1016/s0929-6646(11)60074-0
doi: 10.1016/s0929-6646(11)60074-0
pubmed: 21783017
pmcid: 3169792
Chapman CR, Vierck CJ (2017) The transition of acute postoperative pain to chronic pain: an integrative overview of research on mechanisms. J Pain 18(4):359.e1-359.e38. https://doi.org/10.1016/j.jpain.2016.11.004
doi: 10.1016/j.jpain.2016.11.004
pubmed: 27908839
Yücel A, Ozturk E, Aydoğan MS, Durmuş M, Colak C, Ersoy M (2011) Effects of 2 different doses of pregabalin on morphine consumption and pain after abdominal hysterectomy: a randomized, double-blind clinical trial. Curr Ther Res Clin Exp 72(4):173–183. https://doi.org/10.1016/j.curtheres.2011.06.004
doi: 10.1016/j.curtheres.2011.06.004
pubmed: 24648587
pmcid: 3957155
Imani F, Rahimzadeh P (2012) Gabapentinoids: gabapentin and pregabalin for postoperative pain management. Anesth Pain Med Fall 2(2):52–53. https://doi.org/10.5812/aapm.7743
doi: 10.5812/aapm.7743
Bouwense SA, Olesen SS, Drewes AM, Poley JW, van Goor H, Wilder-Smith OH (2012) Effects of pregabalin on central sensitization in patients with chronic pancreatitis in a randomized, controlled trial. PLoS ONE 7(8):e42096. https://doi.org/10.1371/journal.pone.0042096
doi: 10.1371/journal.pone.0042096
pubmed: 22879908
pmcid: 3412837
Lam DMH, Choi SW, Wong SSC, Irwin MG, Cheung CW (2015) Efficacy of pregabalin in acute postoperative pain under different surgical categories: a meta-analysis. Medicine (Baltimore) 94(46):e1944. https://doi.org/10.1097/md.0000000000001944
doi: 10.1097/md.0000000000001944
pubmed: 26579802
Vélez PA, Lara-Erazo V, Caballero-Lozada AF et al (2023) Preoperative pregabalin prevents succinylcholine-induced fasciculation and myalgia: a meta-analysis of randomized trials. Rev Esp Anestesiol Reanim (Engl Ed). https://doi.org/10.1016/j.redare.2022.12.002
doi: 10.1016/j.redare.2022.12.002
pubmed: 37673208
Calandre EP, Rico-Villademoros F, Slim M (2016) Alpha(2)delta ligands, gabapentin, pregabalin and mirogabalin: a review of their clinical pharmacology and therapeutic use. Expert Rev Neurother 16(11):1263–1277. https://doi.org/10.1080/14737175.2016.1202764
doi: 10.1080/14737175.2016.1202764
pubmed: 27345098
Giménez-Campos MS, Pimenta-Fermisson-Ramos P, Díaz-Cambronero JI, Carbonell-Sanchís R, López-Briz E, Ruíz-García V (2022) A systematic review and meta-analysis of the effectiveness and adverse events of gabapentin and pregabalin for sciatica pain. Aten Primaria 54(1):102144. https://doi.org/10.1016/j.aprim.2021.102144
doi: 10.1016/j.aprim.2021.102144
pubmed: 34637958
Mathieson S, Lin CC, Underwood M, Eldabe S (2020) Pregabalin and gabapentin for pain. BMJ 369:m1315. https://doi.org/10.1136/bmj.m1315
doi: 10.1136/bmj.m1315
pubmed: 32345589
Bockbrader HN, Wesche D, Miller R, Chapel S, Janiczek N, Burger P (2010) A comparison of the pharmacokinetics and pharmacodynamics of pregabalin and gabapentin. Clin Pharmacokinet 49(10):661–669. https://doi.org/10.2165/11536200-000000000-00000
doi: 10.2165/11536200-000000000-00000
pubmed: 20818832
Toth C (2014) Pregabalin: latest safety evidence and clinical implications for the management of neuropathic pain. Ther Adv Drug Saf 5(1):38–56. https://doi.org/10.1177/2042098613505614
doi: 10.1177/2042098613505614
pubmed: 25083261
pmcid: 4110876
Vadivelu N, Mitra S, Schermer E, Kodumudi V, Kaye AD, Urman RD (2014) Preventive analgesia for postoperative pain control: a broader concept. Local Reg Anesth 7:17–22. https://doi.org/10.2147/lra.S62160
doi: 10.2147/lra.S62160
pubmed: 24872720
pmcid: 4012350
Wiffen PJ, Derry S, Bell RF et al (2017) Gabapentin for chronic neuropathic pain in adults. Cochrane Database Syst Rev 6(6):Cd007938. https://doi.org/10.1002/14651858.CD007938.pub4
doi: 10.1002/14651858.CD007938.pub4
pubmed: 28597471
Yang JY, Lee WI, Shin WK, Kim CH, Baik SW, Kim KH (2013) Administration of four different doses of gabapentin reduces awakening from breakthrough pain and adverse effects in outpatients with neuropathic pain during the initial titration. Korean J Anesthesiol 65(1):48–54. https://doi.org/10.4097/kjae.2013.65.1.48
doi: 10.4097/kjae.2013.65.1.48
pubmed: 23904939
pmcid: 3726847
Serpell M, Latymer M, Almas M, Ortiz M, Parsons B, Prieto R (2017) Neuropathic pain responds better to increased doses of pregabalin: an in-depth analysis of flexible-dose clinical trials. J Pain Res 10:1769–1776. https://doi.org/10.2147/jpr.S129832
doi: 10.2147/jpr.S129832
pubmed: 28794656
pmcid: 5536312
Gajraj NM (2007) Pregabalin: its pharmacology and use in pain management. Anesth Analg 105(6):1805–1815. https://doi.org/10.1213/01.ane.0000287643.13410.5e
doi: 10.1213/01.ane.0000287643.13410.5e
pubmed: 18042886
Olmedo-Gaya MV, Manzano-Moreno FJ, Galvez-Mateos R, González-Rodriguez MP, Talero-Sevilla C, Vallecillo-Capilla M (2016) Oral pregabalin for postoperative pain relief after third molar extraction: a randomized controlled clinical trial. Clin Oral Investig 20(7):1819–1826. https://doi.org/10.1007/s00784-015-1657-3
doi: 10.1007/s00784-015-1657-3
pubmed: 26578119
Nissman SA, Tractenberg RE, Babbar-Goel A, Pasternak JF (2008) Oral gabapentin for the treatment of postoperative pain after photorefractive keratectomy. Am J Ophthalmol 145(4):623–629. https://doi.org/10.1016/j.ajo.2007.11.012
doi: 10.1016/j.ajo.2007.11.012
pubmed: 18226799
Freynhagen R, Serpell M, Emir B et al (2015) A comprehensive drug safety evaluation of pregabalin in peripheral neuropathic pain. Pain Pract 15(1):47–57. https://doi.org/10.1111/papr.12146
doi: 10.1111/papr.12146
pubmed: 24279736
Kanbayashi Y, Onishi K, Hosokawa T (2014) Factors predicting adverse events associated with pregabalin administered for neuropathic pain relief. Pain Res Manag 19(6):e164–e167. https://doi.org/10.1155/2014/280549
doi: 10.1155/2014/280549
pubmed: 24945288
pmcid: 4273715
Ghai A, Gupta M, Hooda S, Singla D, Wadhera R (2011) A randomized controlled trial to compare pregabalin with gabapentin for postoperative pain in abdominal hysterectomy. Saudi J Anaesth 5(3):252–257. https://doi.org/10.4103/1658-354x.84097
doi: 10.4103/1658-354x.84097
pubmed: 21957402
pmcid: 3168340
Alimian M, Imani F, Hassani V, Rahimzadeh P, Sharifian M, Safari S (2012) Effects of single-dose pregabalin on postoperative pain in dacryocystorhinostomy surgery. Anesth Pain Med Fall 2(2):72–76. https://doi.org/10.5812/aapm.4301
doi: 10.5812/aapm.4301
Chou R, Gordon DB, de Leon-Casasola OA et al (2016) Management of postoperative pain: a clinical practice guideline from the American pain society, the American society of regional anesthesia and pain medicine, and the American society of anesthesiologists’ committee on regional anesthesia, executive committee, and administrative council. J Pain 17(2):131–157. https://doi.org/10.1016/j.jpain.2015.12.008
doi: 10.1016/j.jpain.2015.12.008
pubmed: 26827847
Verret M, Lauzier F, Zarychanski R et al (2020) Perioperative use of gabapentinoids for the management of postoperative acute pain: a systematic review and meta-analysis. Anesthesiology 133(2):265–279
doi: 10.1097/ALN.0000000000003428
pubmed: 32667154