Exploring retinal vessel density alterations in prolactinoma patients: Insights from OCTA imaging.
Humans
Tomography, Optical Coherence
/ methods
Prolactinoma
/ diagnosis
Male
Female
Retrospective Studies
Adult
Pituitary Neoplasms
/ diagnosis
Fluorescein Angiography
/ methods
Retinal Vessels
/ pathology
Retinal Ganglion Cells
/ pathology
Visual Acuity
/ physiology
Nerve Fibers
/ pathology
Visual Fields
/ physiology
Optic Disk
/ blood supply
Fundus Oculi
Middle Aged
Young Adult
Journal
Indian journal of ophthalmology
ISSN: 1998-3689
Titre abrégé: Indian J Ophthalmol
Pays: India
ID NLM: 0405376
Informations de publication
Date de publication:
01 Nov 2024
01 Nov 2024
Historique:
received:
01
06
2024
accepted:
04
09
2024
medline:
25
10
2024
pubmed:
25
10
2024
entrez:
25
10
2024
Statut:
ppublish
Résumé
To investigate microvascular changes in the macular and peripapillary area in prolactinoma patients by using optical coherence tomography angiography (OCTA). A retrospective study. This study included 40 patients with treatment-naive prolactinoma and 42 healthy controls. Participants underwent comprehensive ophthalmic examinations, visual field testing, and optical coherence tomography (OCT) assessments, including retinal nerve fiber layer (RNFL) thickness, macular, and peripapillary region OCTA by using the Topcon DRI OCT Triton Swept Source-OCT system. The OCTA results were evaluated between groups and then correlated with PRL levels. The differences in best-corrected visual acuities were statistically significant among the groups. The RNFL thickness in the superior and nasal quadrants was significantly lower in the prolactinoma group. The prolactinoma group showed significant reductions in macular vessel density (VD) across all layers than the control group, except in the deep retinal capillary plexus temporal quadrants. The radial peripapillary capillary (RPC) temporal VD in the prolactinoma group was significantly lower. In patients with optic neuropathy, correlations were observed between the RPC temporal and RNFL temporal sectors (r = 0.650, P = 0.03), and between the RPC inferior and RNFL inferior sectors (r = -0.612, P = 0.045). Between PRL levels and OCTA parameters, negative correlations were observed (RPC inferior: r = -0.452, P = 0.003; DCP superior: r = -0.379, P = 0.016). Our study revealed reduced VD in the macula and RPC temporal regions in patients with treatment-naive prolactinoma. OCTA holds significant importance in detecting potential retinopathies and vasculopathies. Future research should focus on examining pre- and post-treatment changes in treatment-naive patients without ON to better understand the impact of prolactinoma.
Identifiants
pubmed: 39449531
doi: 10.4103/IJO.IJO_1301_24
pii: 02223307-202411005-00026
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
S882-S886Informations de copyright
Copyright © 2024 Copyright: © 2024 Indian Journal of Ophthalmology.
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