Aptamer-Based Electrochemical Biosensing Platform for Analysis of Cardiac Biomarkers.
Aptamers, Nucleotide
/ chemistry
Biosensing Techniques
/ methods
Troponin I
/ analysis
Electrochemical Techniques
/ methods
Humans
Biomarkers
/ analysis
Metal-Organic Frameworks
/ chemistry
DNA, Catalytic
/ chemistry
Myocytes, Cardiac
/ chemistry
Limit of Detection
G-Quadruplexes
Gold
/ chemistry
Animals
cardiac troponin I
cardiotoxicity
electrochemical aptasensor
hybridization chain reaction
metal−organic frameworks
Journal
ACS sensors
ISSN: 2379-3694
Titre abrégé: ACS Sens
Pays: United States
ID NLM: 101669031
Informations de publication
Date de publication:
25 Oct 2024
25 Oct 2024
Historique:
medline:
25
10
2024
pubmed:
25
10
2024
entrez:
25
10
2024
Statut:
ppublish
Résumé
Monitoring biomarkers secreted by cardiomyocytes is critical to evaluate anticancer drug-induced myocardial injury (MI). Cardiac troponin I (cTnI) is considered the gold standard biomarker for MI. Herein, an electrochemical aptasensor is engineered for cTnI detection based on lanthanide europium metal-organic frameworks (Eu-MOFs) and a hybridization chain reaction-directed DNAzyme strategy. Three types of Eu-MOF morphologies were easily synthesized by changing the solvent, and the Eu-MOF modulated by mixing the solvent of dimethylformamide and H
Identifiants
pubmed: 39449604
doi: 10.1021/acssensors.4c01594
doi:
Substances chimiques
Aptamers, Nucleotide
0
Troponin I
0
Biomarkers
0
Metal-Organic Frameworks
0
DNA, Catalytic
0
Gold
7440-57-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM