Macrophage accumulation in dorsal root ganglion is associated with neuropathic pain in experimental autoimmune neuritis.
dorsal root ganglion
experimental autoimmune neuritis
macrophages
neuropathic pain
Journal
Translational neuroscience
ISSN: 2081-3856
Titre abrégé: Transl Neurosci
Pays: Germany
ID NLM: 101550327
Informations de publication
Date de publication:
01 Jan 2024
01 Jan 2024
Historique:
received:
16
04
2024
revised:
31
08
2024
accepted:
11
09
2024
medline:
25
10
2024
pubmed:
25
10
2024
entrez:
25
10
2024
Statut:
epublish
Résumé
Neuropathic pain is a common symptom of Guillain-Barré syndrome (GBS). The infiltration of macrophages in the dorsal root ganglion (DRG) contributed to neuropathic pain in nerve injury. The underlying mechanisms of neuropathic pain in patients with GBS remain unknown. Experimental autoimmune neuritis (EAN) is a useful mice model of GBS. Our study aimed to explore whether the infiltration of macrophages in DRG is associated with neuropathic pain of EAN. Male C57BL/6 mice were randomly divided into two groups, the EAN group ( More macrophages infiltrated the DRG of the EAN group in the attack phase and mostly surrounded neurons in the DRG. The proportion of macrophages and pro-inflammatory macrophages in the spleen of mice with EAN was significantly higher than the control group in the attack phase. The infiltration of macrophages in DRG might be associated with neuropathic pain of EAN and pro-inflammatory macrophages may involve in neuropathic pain of EAN.
Sections du résumé
Background
UNASSIGNED
Neuropathic pain is a common symptom of Guillain-Barré syndrome (GBS). The infiltration of macrophages in the dorsal root ganglion (DRG) contributed to neuropathic pain in nerve injury. The underlying mechanisms of neuropathic pain in patients with GBS remain unknown. Experimental autoimmune neuritis (EAN) is a useful mice model of GBS. Our study aimed to explore whether the infiltration of macrophages in DRG is associated with neuropathic pain of EAN.
Methods
UNASSIGNED
Male C57BL/6 mice were randomly divided into two groups, the EAN group (
Results
UNASSIGNED
More macrophages infiltrated the DRG of the EAN group in the attack phase and mostly surrounded neurons in the DRG. The proportion of macrophages and pro-inflammatory macrophages in the spleen of mice with EAN was significantly higher than the control group in the attack phase.
Conclusion
UNASSIGNED
The infiltration of macrophages in DRG might be associated with neuropathic pain of EAN and pro-inflammatory macrophages may involve in neuropathic pain of EAN.
Identifiants
pubmed: 39449726
doi: 10.1515/tnsci-2022-0355
pii: tnsci-2022-0355
pmc: PMC11500528
doi:
Types de publication
Journal Article
Langues
eng
Pagination
20220355Informations de copyright
© 2024 the author(s), published by De Gruyter.
Déclaration de conflit d'intérêts
Conflict of interest: The authors state no conflict of interest.