Association of

SLC19A1 acute lymphoblastic leukemia methotrexate miRNAs oncology pharmacogenetics toxicity

Journal

Current issues in molecular biology
ISSN: 1467-3045
Titre abrégé: Curr Issues Mol Biol
Pays: Switzerland
ID NLM: 100931761

Informations de publication

Date de publication:
16 Oct 2024
Historique:
received: 06 09 2024
revised: 06 10 2024
accepted: 14 10 2024
medline: 25 10 2024
pubmed: 25 10 2024
entrez: 25 10 2024
Statut: epublish

Résumé

Methotrexate (MTX) is an anti-folate chemotherapeutic agent that is considered to be a gold standard in Acute Lymphoblastic Leukemia (ALL) therapy. Nevertheless, toxicities induced mainly due to high doses of MTX are still a challenge for clinical practice. MTX pharmacogenetics implicate various genes as predictors of MTX toxicity, especially those that participate in MTX intake like

Identifiants

DOI: 10.3390/cimb46100685 PMID: 39451565
pubmed: 39451565
pii: cimb46100685
doi: 10.3390/cimb46100685
doi:

Types de publication

Journal Article

Langues

eng

Pagination

11537-11547

Auteurs

Vasiliki Karpa (V)

Laboratory of Medical Biology-Genetics, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Kallirhoe Kalinderi (K)

Laboratory of Medical Biology-Genetics, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Eleni Gavriilaki (E)

2nd Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
ORCID: 0000-0002-8883-8208

Vasiliki Antari (V)

Pediatric & Adolescent Hematology Oncology Unit, 2nd Pediatric Department Faculty of Health Sciences, Aristotle University of Thessaloniki, AHEPA Hospital, S. Kiriakidi 1, 54636 Thessaloniki, Greece.

Emmanuil Hatzipantelis (E)

Pediatric & Adolescent Hematology Oncology Unit, 2nd Pediatric Department Faculty of Health Sciences, Aristotle University of Thessaloniki, AHEPA Hospital, S. Kiriakidi 1, 54636 Thessaloniki, Greece.
ORCID: 0000-0002-7535-2970

Theodora Katopodi (T)

Laboratory of Medical Biology-Genetics, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Liana Fidani (L)

Laboratory of Medical Biology-Genetics, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Pediatric & Adolescent Hematology Oncology Unit, 2nd Pediatric Department Faculty of Health Sciences, Aristotle University of Thessaloniki, AHEPA Hospital, S. Kiriakidi 1, 54636 Thessaloniki, Greece.

Athanasios Tragiannidis (A)

Pediatric & Adolescent Hematology Oncology Unit, 2nd Pediatric Department Faculty of Health Sciences, Aristotle University of Thessaloniki, AHEPA Hospital, S. Kiriakidi 1, 54636 Thessaloniki, Greece.
ORCID: 0000-0003-4294-2605

Classifications MeSH