Mechanisms of Action of Sea Cucumber Triterpene Glycosides Cucumarioside A
Humans
Triple Negative Breast Neoplasms
/ drug therapy
Animals
Triterpenes
/ pharmacology
Cell Line, Tumor
Apoptosis
/ drug effects
Female
Reactive Oxygen Species
/ metabolism
Membrane Potential, Mitochondrial
/ drug effects
Glycosides
/ pharmacology
Sea Cucumbers
/ chemistry
Mice
Antineoplastic Agents
/ pharmacology
Cell Cycle Checkpoints
/ drug effects
Xenograft Model Antitumor Assays
Cucumaria
/ chemistry
Saponins
/ pharmacology
Mice, Inbred BALB C
Mice, Nude
anticancer activity
breast cancer
mitochondrial apoptotic pathway
molecular mechanisms
triterpene glycosides
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
17 Oct 2024
17 Oct 2024
Historique:
received:
17
08
2024
revised:
11
10
2024
accepted:
14
10
2024
medline:
25
10
2024
pubmed:
25
10
2024
entrez:
25
10
2024
Statut:
epublish
Résumé
Breast cancer is the most prevalent form of cancer in women worldwide. Triple-negative breast cancer is the most unfavorable for patients, but it is also the most sensitive to chemotherapy. Triterpene glycosides from sea cucumbers possess a high therapeutic potential as anticancer agents. This study aimed to identify the pathways triggered and regulated in MDA-MB-231 cells (triple-negative breast cancer cell line) by the glycosides cucumarioside A
Identifiants
pubmed: 39452882
pii: md22100474
doi: 10.3390/md22100474
pii:
doi:
Substances chimiques
Triterpenes
0
Reactive Oxygen Species
0
Glycosides
0
cucumarioside
74434-21-2
Antineoplastic Agents
0
Saponins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Russian Science Foundation
ID : 23-13-00078