Effects of Propolis Supplementation on Gut Microbiota and Uremic Toxin Profiles of Patients Undergoing Hemodialysis.
Humans
Gastrointestinal Microbiome
/ drug effects
Propolis
Renal Dialysis
Male
Female
Middle Aged
Aged
Uremic Toxins
/ blood
Double-Blind Method
Feces
/ microbiology
Dietary Supplements
Renal Insufficiency, Chronic
/ therapy
Indican
/ blood
Indoleacetic Acids
/ blood
Sulfuric Acid Esters
/ blood
Uremia
/ therapy
Cytokines
/ blood
Bacteria
/ genetics
Cresols
CKD
chronic kidney disease
hemodialysis
microbiome
propolis
uremic toxins
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
25 Sep 2024
25 Sep 2024
Historique:
received:
23
07
2024
revised:
19
09
2024
accepted:
20
09
2024
medline:
25
10
2024
pubmed:
25
10
2024
entrez:
25
10
2024
Statut:
epublish
Résumé
Propolis possesses many bioactive compounds that could modulate the gut microbiota and reduce the production of uremic toxins in patients with chronic kidney disease (CKD) undergoing hemodialysis (HD). This clinical trial aimed to evaluate the effects of propolis on the gut microbiota profile and uremic toxin plasma levels in HD patients. These are secondary analyses from a previous double-blind, randomized clinical study, with 42 patients divided into two groups: the placebo and propolis group received 400 mg of green propolis extract/day for eight weeks. Indole-3 acetic acid (IAA), indoxyl sulfate (IS), and p-cresyl sulfate (p-CS) plasma levels were evaluated by reversed-phase liquid chromatography, and cytokines were investigated using the multiplex assay (Bio-Plex Magpix
Sections du résumé
BACKGROUND
BACKGROUND
Propolis possesses many bioactive compounds that could modulate the gut microbiota and reduce the production of uremic toxins in patients with chronic kidney disease (CKD) undergoing hemodialysis (HD). This clinical trial aimed to evaluate the effects of propolis on the gut microbiota profile and uremic toxin plasma levels in HD patients. These are secondary analyses from a previous double-blind, randomized clinical study, with 42 patients divided into two groups: the placebo and propolis group received 400 mg of green propolis extract/day for eight weeks. Indole-3 acetic acid (IAA), indoxyl sulfate (IS), and p-cresyl sulfate (p-CS) plasma levels were evaluated by reversed-phase liquid chromatography, and cytokines were investigated using the multiplex assay (Bio-Plex Magpix
Identifiants
pubmed: 39453192
pii: toxins16100416
doi: 10.3390/toxins16100416
pii:
doi:
Substances chimiques
Propolis
9009-62-5
Uremic Toxins
0
Indican
N187WK1Y1J
Indoleacetic Acids
0
4-cresol sulfate
56M34ZQY1S
Sulfuric Acid Esters
0
indoleacetic acid
6U1S09C61L
Cytokines
0
Cresols
0
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM