An innovative electrical neurostimulation approach to mimic reflexive urination control in spinal cord injury models.
Animals
Spinal Cord Injuries
/ therapy
Mice
Urination
/ physiology
Disease Models, Animal
Electric Stimulation Therapy
/ methods
Urinary Bladder
/ physiopathology
Female
Muscle Contraction
Electromyography
Mice, Inbred C57BL
Pudendal Nerve
/ physiopathology
Electric Stimulation
/ methods
Urinary Bladder, Neurogenic
/ therapy
Urethra
/ physiopathology
Electrical neurostimulation
Major pelvic ganglion
Neurogenic lower urinary tract dysfunction
Pudendal nerve
Spinal cord injury
Urination control
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
25 Oct 2024
25 Oct 2024
Historique:
received:
04
07
2024
accepted:
14
10
2024
medline:
26
10
2024
pubmed:
26
10
2024
entrez:
25
10
2024
Statut:
epublish
Résumé
Neurogenic lower urinary tract dysfunction (NLUTD) is a frequent consequence of spinal cord injury (SCI), leading to symptoms that significantly impact quality of life. Although many life-saving techniques are available, current treatment strategies for managing NLUTD still exhibit limitations and drawbacks. Here, we introduce a new electrical neuromodulation strategy involving electrical stimulation of the major pelvic ganglion (MPG) to initiate bladder contraction, in conjunction with innovative programmable (IPG) electrical stimulation on the pudendal nerve (PN) to induce external urethral sphincter (EUS) relaxation in freely moving or anesthetized SCI mice. Furthermore, we conducted the void spot assay, and cystometry coupled with EUS electromyography (EMG) recordings to evaluate voiding function, and monitor bladder pressure and EUS activity. Our findings demonstrate that our novel electrical neuromodulation approach effectively triggers coordinated bladder muscle contraction and EUS relaxation, effectively counteracting SCI-induced NLUTD. Additionally, this electrical neuromodulation method enhances voiding efficiency, closely resembling natural reflexive urination in SCI mice. Thus, our study offers a promising electrical neurostimulation approach aimed at restoring physiological coordination and potentially offering personalized treatment for improving voiding efficiency in individuals with SCI-associated NLUTD.
Identifiants
pubmed: 39455718
doi: 10.1038/s41598-024-76499-3
pii: 10.1038/s41598-024-76499-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
25305Subventions
Organisme : National Natural Science Foundation of China
ID : 31970946
Organisme : Talent Project of chongqing
ID : 4246ZP1252
Organisme : China Postdoctoral Science Foundation
ID : 2021M70602
Informations de copyright
© 2024. The Author(s).
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