The wonders of X-PDT: an advance route to cancer theranostics.
Deep tumors
ROS
Theranostic
X-PDT
X-ray responsive imaging
Journal
Journal of nanobiotechnology
ISSN: 1477-3155
Titre abrégé: J Nanobiotechnology
Pays: England
ID NLM: 101152208
Informations de publication
Date de publication:
25 Oct 2024
25 Oct 2024
Historique:
received:
01
07
2024
accepted:
11
10
2024
medline:
26
10
2024
pubmed:
26
10
2024
entrez:
26
10
2024
Statut:
epublish
Résumé
Global mortality data indicates cancer as the second-leading cause of death worldwide. Therefore, there's a pressing need to innovate effective treatments to address this significant medical and societal challenge. In recent years, X-ray-induced photodynamic therapy (X-PDT) has emerged as a promising advancement, revolutionizing traditional photodynamic therapy (PDT) for deeply entrenched malignancies by harnessing penetrating X-rays as external stimuli. Recent developments in X-ray photodynamic therapy have shown a trend toward minimizing radiation doses to remarkably low levels after the proof-of-concept demonstration. Early detection and real-time monitoring are crucial aspects of effective cancer treatment. Sophisticated X-ray imaging techniques have been enhanced by the introduction of X-ray luminescence nano-agents, alongside contrast nanomaterials based on X-ray attenuation. X-ray luminescence-based in vivo imaging offers excellent detection sensitivity and superior image quality in deep tissues at a reasonable cost, due to unhindered penetration and unimpeded auto-fluorescence of X-rays. This review emphasizes the significance of X-ray responsive theranostics, exploring their mechanism of action, feasibility, biocompatibility, and promising prospects in imaging-guided therapy for deep-seated tumors. Additionally, it discusses promising applications of X-PDT in treating breast cancer, liver cancer, lung cancer, skin cancer, and colorectal cancer.
Identifiants
pubmed: 39456085
doi: 10.1186/s12951-024-02931-5
pii: 10.1186/s12951-024-02931-5
doi:
Substances chimiques
Photosensitizing Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
655Subventions
Organisme : the Postdoctoral funding Grant
ID : 02080100-K3F113001
Organisme : the National Natural Science Foundation of China
ID : T2293753
Organisme : the 2023 Hangzhou West Lake Pearl Project Leading Innovative Youth Team Project
ID : TD2023017
Informations de copyright
© 2024. The Author(s).
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