Modulation of Carnitine Palmitoyl Transferase 1b Expression and Activity in Muscle Pathophysiology in Osteoarthritis and Osteoporosis.

Humans Carnitine O-Palmitoyltransferase / metabolism Osteoarthritis / metabolism Osteoporosis / metabolism Male Female Middle Aged Aged Muscle, Skeletal / metabolism Myoblasts / metabolism Oxidative Stress Reactive Oxygen Species / metabolism
energy metabolism mitochondria biogenesis muscle atrophy myoblast regeneration osteoarthritis osteoporosis oxidative stress

Journal

Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414

Informations de publication

Date de publication:
12 Oct 2024
Historique:
received: 11 07 2024
revised: 07 10 2024
accepted: 10 10 2024
medline: 26 10 2024
pubmed: 26 10 2024
entrez: 26 10 2024
Statut: epublish

Résumé

In the pathophysiology of osteoarthritis and osteoporosis, articular cartilage and bone represent the target tissues, respectively, but muscle is also involved. Since many changes in energy metabolism occur in muscle with aging, the aim of the present work was to investigate the involvement of carnitine palmitoyl transferase 1b (Cpt1b) in the muscle pathophysiology of the two diseases. Healthy subjects (CTR,

Identifiants

DOI: 10.3390/biom14101289 PMID: 39456222
pubmed: 39456222
pii: biom14101289
doi: 10.3390/biom14101289
pii:
doi:

Substances chimiques

Carnitine O-Palmitoyltransferase EC 2.3.1.21
CPT1B protein, human EC 2.3.1.21
Reactive Oxygen Species 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Chiara Greggi (C)

Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
ORCID: 0000-0003-3205-4030

Manuela Montanaro (M)

Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
ORCID: 0000-0001-8441-3731

Maria Giovanna Scioli (MG)

Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
ORCID: 0000-0002-8458-4108

Martina Puzzuoli (M)

Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.

Sonia Gino Grillo (S)

Department of Orthopaedics and Traumatology, "Policlinico Tor Vergata" Foundation, Viale Oxford 81, 00133 Rome, Italy.

Manuel Scimeca (M)

Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
ORCID: 0000-0003-0585-1309

Alessandro Mauriello (A)

Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
ORCID: 0000-0002-7351-5676

Augusto Orlandi (A)

Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Faculty of Medicine and Surgery, University "Our Lady of Good Counsel", Rruga Dritan Hoxha, 1000 Tirana, Albania.
ORCID: 0000-0001-7202-5854

Elena Gasbarra (E)

Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Department of Orthopaedics and Traumatology, "Policlinico Tor Vergata" Foundation, Viale Oxford 81, 00133 Rome, Italy.

Riccardo Iundusi (R)

Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Department of Orthopaedics and Traumatology, "Policlinico Tor Vergata" Foundation, Viale Oxford 81, 00133 Rome, Italy.

Sabina Pucci (S)

Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.

Umberto Tarantino (U)

Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
Department of Orthopaedics and Traumatology, "Policlinico Tor Vergata" Foundation, Viale Oxford 81, 00133 Rome, Italy.
Faculty of Medicine and Surgery, University "Our Lady of Good Counsel", Rruga Dritan Hoxha, 1000 Tirana, Albania.
ORCID: 0000-0003-0330-2189

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Modulation of Carnitine Palmitoyl Transferase...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Acyltransferases › Carnitine acyltransferases › Carnitine O-palmitoyltransferase › Modulation of Carnitine Palmitoyl Transferase...
questionsmedicales.fr › Maladies ostéomusculaires › Arthrose › Modulation of Carnitine Palmitoyl Transferase...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Maladies osseuses métaboliques › Ostéoporose › Modulation of Carnitine Palmitoyl Transferase...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Modulation of Carnitine Palmitoyl Transferase...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Modulation of Carnitine Palmitoyl Transferase...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › Modulation of Carnitine Palmitoyl Transferase...
questionsmedicales.fr › Cellules › Cellules souches › Myoblastes › Modulation of Carnitine Palmitoyl Transferase...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Modulation of Carnitine Palmitoyl Transferase...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Modulation of Carnitine Palmitoyl Transferase...