Metagenomic Study Reveals Phage-Bacterial Interactome Dynamics in Gut and Oral Microbiota in Pancreatic Diseases.
Humans
Gastrointestinal Microbiome
Metagenomics
/ methods
Bacteriophages
/ genetics
Feces
/ microbiology
Pancreatic Neoplasms
/ microbiology
Male
Mouth
/ microbiology
Saliva
/ microbiology
Female
Middle Aged
Carcinoma, Pancreatic Ductal
/ microbiology
Bacteria
/ genetics
Metagenome
Pancreatitis, Chronic
/ microbiology
Pancreatic Diseases
/ microbiology
Aged
Microbiota
/ genetics
Adult
bacteria
chronic pancreatitis
gut microbiome
metagenome analysis
oral microbiome
pancreatic cancer
pancreatic diseases
phage–bacterial interactome
virus
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Oct 2024
12 Oct 2024
Historique:
received:
06
09
2024
revised:
04
10
2024
accepted:
10
10
2024
medline:
26
10
2024
pubmed:
26
10
2024
entrez:
26
10
2024
Statut:
epublish
Résumé
Individuals with pancreatic-related health conditions usually show lower diversity and different composition of bacterial and viral species between the gut and oral microbiomes compared to healthy individuals. We performed a thorough microbiome analysis, using deep shotgun sequencing of stool and saliva samples obtained from patients with chronic pancreatitis (CP), pancreatic ductal adenocarcinoma (PDAC), and healthy controls (HCs).We observed similar microbiota composition at the species level in both the gut and oral samples in PDAC patients compared to HCs, among which the most distinctive finding was that the abundance of oral-originated
Identifiants
pubmed: 39456772
pii: ijms252010988
doi: 10.3390/ijms252010988
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fundació la Marató de TV3
ID : 201912-31
Organisme : European Molecular Biology Organization
ID : 9986