TGFB2 mRNA Levels Prognostically Interact with Interferon-Alpha Receptor Activation of IRF9 and IFI27, and an Immune Checkpoint LGALS9 to Impact Overall Survival in Pancreatic Ductal Adenocarcinoma.
Humans
Carcinoma, Pancreatic Ductal
/ genetics
Pancreatic Neoplasms
/ genetics
Prognosis
RNA, Messenger
/ genetics
Female
Male
Gene Expression Regulation, Neoplastic
Transforming Growth Factor beta2
/ genetics
Interferon-Stimulated Gene Factor 3, gamma Subunit
/ genetics
Middle Aged
Aged
Receptor, Interferon alpha-beta
/ genetics
Membrane Proteins
/ genetics
Biomarkers, Tumor
/ genetics
Galectins
PDAC
RNAseq
TAMs
TGF beta
TGFB2
biomarkers
immune checkpoint
interferon-alpha receptor
mRNA
pancreatic cancer
tumor microenvironment
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
18 Oct 2024
18 Oct 2024
Historique:
received:
23
08
2024
revised:
13
09
2024
accepted:
16
10
2024
medline:
26
10
2024
pubmed:
26
10
2024
entrez:
26
10
2024
Statut:
epublish
Résumé
The treatment of pancreatic ductal adenocarcinoma (PDAC) is an unmet challenge, with the median overall survival rate remaining less than a year, even with the use of FOLFIRINOX-based therapies. This study analyzed archived macrophage-associated mRNA expression using datasets deposited in the UCSC Xena web platform to compare normal pancreatic tissue and PDAC tumor samples. The
Identifiants
pubmed: 39457004
pii: ijms252011221
doi: 10.3390/ijms252011221
pii:
doi:
Substances chimiques
RNA, Messenger
0
Transforming Growth Factor beta2
0
Interferon-Stimulated Gene Factor 3, gamma Subunit
0
LGALS9 protein, human
0
TGFB2 protein, human
0
Receptor, Interferon alpha-beta
156986-95-7
Membrane Proteins
0
Biomarkers, Tumor
0
Galectins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM