Design and Synthesis of Potential Multi-Target Antidepressants: Exploration of 1-(4-(7-Azaindole)-3,6-dihydropyridin-1-yl)alkyl-3-(1

Serotonin Plasma Membrane Transport Proteins / metabolism Antidepressive Agents / pharmacology Humans Structure-Activity Relationship Drug Design Indoles / pharmacology Pyrrolidines / pharmacology Dopamine Plasma Membrane Transport Proteins / metabolism Animals Receptor, Serotonin, 5-HT1A / metabolism Receptors, Dopamine D2 / metabolism
5-HT1A receptor ligands antidepressant drugs drug design and discovery multi-target directed ligands serotonin reuptake inhibitors triple reuptake inhibitors

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
20 Oct 2024
Historique:
received: 24 09 2024
revised: 10 10 2024
accepted: 16 10 2024
medline: 26 10 2024
pubmed: 26 10 2024
entrez: 26 10 2024
Statut: epublish

Résumé

We describe the design, synthesis and structure-activity relationship of a novel series of 1-(4-(7-azaindole)-3,6-dihydropyridin-1-yl)alkyl-3-(1

Identifiants

DOI: 10.3390/ijms252011276 PMID: 39457057
pubmed: 39457057
pii: ijms252011276
doi: 10.3390/ijms252011276
pii:
doi:

Substances chimiques

Serotonin Plasma Membrane Transport Proteins 0
Antidepressive Agents 0
Indoles 0
Pyrrolidines 0
Dopamine Plasma Membrane Transport Proteins 0
Receptor, Serotonin, 5-HT1A 112692-38-3
Receptors, Dopamine D2 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Science Center
ID : 2013/09/B/NZ7/00748

Auteurs

Martyna Z Wróbel (MZ)

Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warszawa, Poland.
ORCID: 0000-0001-6201-4756

Andrzej Chodkowski (A)

Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warszawa, Poland.

Agata Siwek (A)

Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland.

Grzegorz Satała (G)

Department of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343 Kraków, Poland.

Andrzej J Bojarski (AJ)

Department of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343 Kraków, Poland.
ORCID: 0000-0003-1417-6333

Maciej Dawidowski (M)

Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097 Warszawa, Poland.
ORCID: 0000-0002-7262-5718

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs de la sérotonine › Design and Synthesis of Potential Multi-Target...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Psychoanaleptiques › Antidépresseurs › Design and Synthesis of Potential Multi-Target...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Design and Synthesis of Potential Multi-Target...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Design and Synthesis of Potential Multi-Target...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Design and Synthesis of Potential Multi-Target...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › Design and Synthesis of Potential Multi-Target...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrrolidines › Design and Synthesis of Potential Multi-Target...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs de la dopamine › Design and Synthesis of Potential Multi-Target...
questionsmedicales.fr › Eucaryotes › Animaux › Design and Synthesis of Potential Multi-Target...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs sérotoninergiques › Récepteurs de la sérotonine de type 5-HT1 › Récepteur de la sérotonine de type 5-HT1A › Design and Synthesis of Potential Multi-Target...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs catécholaminergiques › Récepteurs dopaminergiques › Récepteur D2 de la dopamine › Design and Synthesis of Potential Multi-Target...