Prediction of Whole Liver Graft Weight Based on Biometric Variables in Paediatric and Adult Liver Donors.

linear regression liver transplantation model

Journal

Children (Basel, Switzerland)
ISSN: 2227-9067
Titre abrégé: Children (Basel)
Pays: Switzerland
ID NLM: 101648936

Informations de publication

Date de publication:
16 Oct 2024
Historique:
received: 21 08 2024
revised: 07 10 2024
accepted: 11 10 2024
medline: 26 10 2024
pubmed: 26 10 2024
entrez: 26 10 2024
Statut: epublish

Résumé

In paediatric liver transplantation, donor-recipient compatibility depends on graft size. We explored whether the graft weight can be predicted using the donor's biometric parameters. We used seven easily available biometric variables in 142 anonymised paediatric and adult donors, with data collected between 2016 and 2022. The whole or partial liver was transplanted in our hospital from these donors. We identified the variables that had the strongest correlation to our response variable: whole liver graft weight. In child donors, we determined two linear models: using donor weight and height on the one hand and using donor weight and right liver span on the other hand. Both models had a coefficient of determination R In clinical practise, our models could provide rapidly accessible estimates to determine whole graft dimension compatibility in liver transplantation in children and adults. Determining similar models predicting the left lobe and lateral segment weight could prove invaluable in paediatric transplantation.

Sections du résumé

BACKGROUND/OBJECTIVES OBJECTIVE
In paediatric liver transplantation, donor-recipient compatibility depends on graft size. We explored whether the graft weight can be predicted using the donor's biometric parameters.
METHODS METHODS
We used seven easily available biometric variables in 142 anonymised paediatric and adult donors, with data collected between 2016 and 2022. The whole or partial liver was transplanted in our hospital from these donors. We identified the variables that had the strongest correlation to our response variable: whole liver graft weight.
RESULTS RESULTS
In child donors, we determined two linear models: using donor weight and height on the one hand and using donor weight and right liver span on the other hand. Both models had a coefficient of determination R
CONCLUSIONS CONCLUSIONS
In clinical practise, our models could provide rapidly accessible estimates to determine whole graft dimension compatibility in liver transplantation in children and adults. Determining similar models predicting the left lobe and lateral segment weight could prove invaluable in paediatric transplantation.

Identifiants

pubmed: 39457213
pii: children11101248
doi: 10.3390/children11101248
pii:
doi:

Types de publication

Journal Article

Langues

eng

Auteurs

Maria Kuksin (M)

Department of Clinical Research, Assistance Publique-Hôpitaux de Paris, Université Paris-Saclay, Bicêtre Hospital, 78 Rue du Général Leclerc, 94270 Le Kremlin Bicêtre, France.

Valeska Bidault Jourdainne (V)

Department of Paediatric Surgery, Hôpital Mère-Enfant, Hospices Civils de Lyon, 59 Boulevard Pinel, 69500 Bron, France.

Guillaume Rossignol (G)

Department of Paediatric Surgery, Hôpital Mère-Enfant, Hospices Civils de Lyon, 59 Boulevard Pinel, 69500 Bron, France.

Philippe Aegerter (P)

Department of Public Health-U1018 UVSSQ INSERM, GIRCI IdF-UFR Médecine Paris-Ile de France Ouest Université Versailles Saint Quentin, 9 Avenue Charles de Gaulle, 92100 Boulogne, France.

Géraldine Hery (G)

Department of Paediatric Surgery, Assistance Publique-Hôpitaux de Paris, Université Paris-Saclay, Bicêtre Hospital, 78 Rue du Général Leclerc, 94270 Le Kremlin Bicêtre, France.

Jean-Paul Teglas (JP)

Department of Clinical Research, Assistance Publique-Hôpitaux de Paris, Université Paris-Saclay, Bicêtre Hospital, 78 Rue du Général Leclerc, 94270 Le Kremlin Bicêtre, France.

Virginie Fouquet (V)

Department of Paediatric Surgery, Assistance Publique-Hôpitaux de Paris, Université Paris-Saclay, Bicêtre Hospital, 78 Rue du Général Leclerc, 94270 Le Kremlin Bicêtre, France.

Sophie Branchereau (S)

Department of Paediatric Surgery, Assistance Publique-Hôpitaux de Paris, Université Paris-Saclay, Bicêtre Hospital, 78 Rue du Général Leclerc, 94270 Le Kremlin Bicêtre, France.

Florent Guérin (F)

Department of Paediatric Surgery, Assistance Publique-Hôpitaux de Paris, Université Paris-Saclay, Bicêtre Hospital, 78 Rue du Général Leclerc, 94270 Le Kremlin Bicêtre, France.

Classifications MeSH