The Human 8-oxoG DNA Glycosylase 1 (
8-oxoguanine DNA glycosylase 1
infertility
semen
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
09 Oct 2024
09 Oct 2024
Historique:
received:
14
09
2024
revised:
04
10
2024
accepted:
07
10
2024
medline:
26
10
2024
pubmed:
26
10
2024
entrez:
26
10
2024
Statut:
epublish
Résumé
8-hydroxy-2'-deoxyguanosine (8-OHdG) is a form of oxidative DNA damage caused by oxidative stress (OS), which is considered a major factor in male infertility. The cellular defense system against 8-OHdG involves base excision repair (BER) with the enzyme 8-Oxoguanine DNA glycosylase 1 (OGG1). However, studies on the single-nucleotide polymorphism (SNP) OGG1 Polymorphic screening was performed using TaqMan allelic discrimination assays, and oxidative DNA damage was evaluated through the quantification of 8-OHdG and total antioxidant capacity (TAC); in addition, electrical bioimpedance spectroscopy (EBiS) measurements were used as a reference for different electrical properties associated with 8-OHdG concentrations. The detected The
Sections du résumé
BACKGROUND/OBJECTIVES
OBJECTIVE
8-hydroxy-2'-deoxyguanosine (8-OHdG) is a form of oxidative DNA damage caused by oxidative stress (OS), which is considered a major factor in male infertility. The cellular defense system against 8-OHdG involves base excision repair (BER) with the enzyme 8-Oxoguanine DNA glycosylase 1 (OGG1). However, studies on the single-nucleotide polymorphism (SNP) OGG1
METHODS
METHODS
Polymorphic screening was performed using TaqMan allelic discrimination assays, and oxidative DNA damage was evaluated through the quantification of 8-OHdG and total antioxidant capacity (TAC); in addition, electrical bioimpedance spectroscopy (EBiS) measurements were used as a reference for different electrical properties associated with 8-OHdG concentrations.
RESULTS
RESULTS
The detected
CONCLUSIONS
CONCLUSIONS
The
Identifiants
pubmed: 39457598
pii: biomedicines12102286
doi: 10.3390/biomedicines12102286
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : The Instituto Politécnico Nacional Secretaria de Investigación y Posgrado
ID : SIP20230328, SIP Innovation2023272