Comparison of Dietary Supplementation with Krill Oil, Fish Oil, and Astaxanthin on an Experimental Ethanol-Induced Gastric Ulcer Model: A Biochemical and Histological Study.
Animals
Stomach Ulcer
/ chemically induced
Fish Oils
/ pharmacology
Xanthophylls
/ pharmacology
Euphausiacea
/ chemistry
Dietary Supplements
Ethanol
Rats, Sprague-Dawley
Male
Disease Models, Animal
Malondialdehyde
/ metabolism
Rats
Lipid Peroxidation
/ drug effects
Gastric Mucosa
/ drug effects
Peroxidase
/ metabolism
Glutathione
/ metabolism
Oxidative Stress
/ drug effects
antioxidant
astaxanthin
fish oil
gastric ulcer
krill oil
liver
oxidative stress
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
10 Oct 2024
10 Oct 2024
Historique:
received:
16
09
2024
revised:
02
10
2024
accepted:
04
10
2024
medline:
26
10
2024
pubmed:
26
10
2024
entrez:
26
10
2024
Statut:
epublish
Résumé
Despite advances in ulcer treatment research, the search for new, safe, and effective strategies for preventing and treating ulcer diseases persists. In this study, the protective effects of dietary supplementation with krill oil (KO), fish oil (FO), and astaxanthin (ASX) on an ethanol-induced gastric ulcer model were compared during biochemical and histological observations. Sprague-Dawley ( The ulcer group showed increased levels of malondialdehyde (MDA), chemiluminescence (CL), and myeloperoxidase (MPO) activity and decreased levels of glutathione in the gastric tissues. While KO, FO, and ASX supplementation decreased chemiluminescence levels in the ulcer group, only ASX supplementation decreased MDA levels and MPO activity. In conclusion, supplementation with KO or FO has a similar protective effect against ethanol-induced ulcer damage, as it inhibits ROS formation and reduces lipid peroxidation. However, ASX supplementation has a higher protective effect than KO or FO supplementations against experimental ethanol-induced gastric lesions in rats, as it inhibits ROS formation and reduces neutrophil infiltration and lipid peroxidation.
Sections du résumé
BACKGROUND/OBJECTIVES
OBJECTIVE
Despite advances in ulcer treatment research, the search for new, safe, and effective strategies for preventing and treating ulcer diseases persists.
METHODS
METHODS
In this study, the protective effects of dietary supplementation with krill oil (KO), fish oil (FO), and astaxanthin (ASX) on an ethanol-induced gastric ulcer model were compared during biochemical and histological observations. Sprague-Dawley (
RESULTS
RESULTS
The ulcer group showed increased levels of malondialdehyde (MDA), chemiluminescence (CL), and myeloperoxidase (MPO) activity and decreased levels of glutathione in the gastric tissues. While KO, FO, and ASX supplementation decreased chemiluminescence levels in the ulcer group, only ASX supplementation decreased MDA levels and MPO activity.
CONCLUSIONS
CONCLUSIONS
In conclusion, supplementation with KO or FO has a similar protective effect against ethanol-induced ulcer damage, as it inhibits ROS formation and reduces lipid peroxidation. However, ASX supplementation has a higher protective effect than KO or FO supplementations against experimental ethanol-induced gastric lesions in rats, as it inhibits ROS formation and reduces neutrophil infiltration and lipid peroxidation.
Identifiants
pubmed: 39458422
pii: nu16203426
doi: 10.3390/nu16203426
pii:
doi:
Substances chimiques
astaxanthine
8XPW32PR7I
Fish Oils
0
Xanthophylls
0
Ethanol
3K9958V90M
Malondialdehyde
4Y8F71G49Q
Peroxidase
EC 1.11.1.7
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Comparative Study
Langues
eng
Sous-ensembles de citation
IM