The Assembly of HTLV-1-How Does It Differ from HIV-1?

HIV-1 / physiology Virus Assembly Humans Human T-lymphotropic virus 1 / genetics Gene Products, gag / metabolism Cell Membrane / metabolism Virus Replication
Gag polyprotein capsid (CA) human T-cell leukemia virus type 1 (HTLV-1) human immunodeficiency virus type 1 (HIV-1) matrix (MA) phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) plasma membrane (PM)

Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
27 Sep 2024
Historique:
received: 18 08 2024
revised: 21 09 2024
accepted: 25 09 2024
medline: 26 10 2024
pubmed: 26 10 2024
entrez: 26 10 2024
Statut: epublish

Résumé

Retroviral assembly is a highly coordinated step in the replication cycle. The process is initiated when the newly synthesized Gag and Gag-Pol polyproteins are directed to the inner leaflet of the plasma membrane (PM), where they facilitate the budding and release of immature viral particles. Extensive research over the years has provided crucial insights into the molecular determinants of this assembly step. It is established that Gag targeting and binding to the PM is mediated by interactions of the matrix (MA) domain and acidic phospholipids such as phosphatidylinositol 4,5-bisphosphate (PI(4,5)P

Identifiants

DOI: 10.3390/v16101528 PMID: 39459862
pubmed: 39459862
pii: v16101528
doi: 10.3390/v16101528
pii:
doi:

Substances chimiques

Gene Products, gag 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH HHS
ID : 1R01GM151775-01A1
Pays : United States
Organisme : NIH HHS
ID : R21DE032878
Pays : United States
Organisme : NIH HHS
ID : R37AI150901-14
Pays : United States

Auteurs

Dominik Herrmann (D)

Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
ORCID: 0000-0002-7187-3357

Shuyu Meng (S)

Institute for Molecular Virology, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.
Molecular Pharmacology and Therapeutics Graduate Program, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.
ORCID: 0000-0002-7951-6450

Huixin Yang (H)

Institute for Molecular Virology, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.
ORCID: 0000-0003-0539-0477

Louis M Mansky (LM)

Institute for Molecular Virology, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.
Molecular Pharmacology and Therapeutics Graduate Program, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.
Department of Diagnostic and Biological Sciences, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.
Masonic Cancer Center, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA.
ORCID: 0000-0003-2391-1061

Jamil S Saad (JS)

Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
ORCID: 0000-0001-9503-6484

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Classifications MeSH

questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › The Assembly of HTLV-1-How Does It Differ from HIV-1?
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Assemblage viral › The Assembly of HTLV-1-How Does It Differ from HIV-1?
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Assembly of HTLV-1-How Does It Differ from HIV-1?
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Deltaretrovirus › Virus T-lymphotrope de type 1 des primates › Virus T-lymphotrope humain de type 1 › The Assembly of HTLV-1-How Does It Differ from HIV-1?
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales structurales › Protéines nucléocapside › Protéines du core viral › Produits du gène gag › The Assembly of HTLV-1-How Does It Differ from HIV-1?
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › The Assembly of HTLV-1-How Does It Differ from HIV-1?
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › The Assembly of HTLV-1-How Does It Differ from HIV-1?