Understanding the Omicron Variant Impact in Healthcare Workers: Insights from the Prospective COVID-19 Post-Immunization Serological Cohort in Munich (KoCo-Impf) on Risk Factors for Breakthrough and Reinfections.


Journal

Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722

Informations de publication

Date de publication:
30 Sep 2024
Historique:
received: 26 07 2024
revised: 09 09 2024
accepted: 25 09 2024
medline: 26 10 2024
pubmed: 26 10 2024
entrez: 26 10 2024
Statut: epublish

Résumé

This study analyzes immune responses to SARS-CoV-2 vaccination and infection, including asymptomatic cases, focusing on infection risks during the Omicron wave, particularly among high-risk healthcare workers. In the KoCo-Impf study, we monitored 6088 vaccinated participants in Munich aged 18 and above. From 13 May to 31 July 2022, 2351 participants were follow-uped. Logistic regression models evaluated primary, secondary, and breakthrough infections (BTIs). Roche Elecsys

Identifiants

pubmed: 39459890
pii: v16101556
doi: 10.3390/v16101556
pii:
doi:

Substances chimiques

Antibodies, Viral 0
COVID-19 Vaccines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : European Union
ID : Grant Agreement No. 101016167

Auteurs

Christian Janke (C)

Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, 80802 Munich, Germany.

Raquel Rubio-Acero (R)

Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, 80802 Munich, Germany.

Maximilian Weigert (M)

Statistical Consulting Unit StaBLab, Department of Statistics, LMU Munich, 80539 Munich, Germany.
Munich Center for Machine Learning (MCML), 80539 Munich, Germany.

Christina Reinkemeyer (C)

Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, 80802 Munich, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, 80799 Munich, Germany.

Yeganeh Khazaei (Y)

Statistical Consulting Unit StaBLab, Department of Statistics, LMU Munich, 80539 Munich, Germany.

Lisa Kleinlein (L)

Statistical Consulting Unit StaBLab, Department of Statistics, LMU Munich, 80539 Munich, Germany.

Ronan Le Gleut (R)

Institute of Computational Biology, Helmholtz Munich, 85764 Neuherberg, Germany.
Core Facility Statistical Consulting, Helmholtz Munich, 85764 Neuherberg, Germany.

Katja Radon (K)

Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, LMU University Hospital, LMU Munich, 80336 Munich, Germany.
Center for International Health (CIH), LMU University Hospital, LMU Munich, 80336 Munich, Germany.
Comprehensive Pneumology Center (CPC) Munich, German Center for Lung Research (DZL), 89337 Munich, Germany.

Marlene Hannes (M)

Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, 80802 Munich, Germany.
Unit Global Health, Helmholtz Zentrum München, German Research Centre for Environmental Health (HMGU), 85764 Neuherberg, Germany.

Francesco Picasso (F)

Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, 80802 Munich, Germany.

Anne Elisabeth Lucke (AE)

Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, 80802 Munich, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, 80799 Munich, Germany.

Michael Plank (M)

Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, 80802 Munich, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, 80799 Munich, Germany.

Irene Charlotte Kotta (IC)

Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, 80802 Munich, Germany.

Ivana Paunovic (I)

Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, 80802 Munich, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, 80799 Munich, Germany.

Ana Zhelyazkova (A)

Institut für Notfallmedizin und Medizinmanagement (INM), LMU Klinikum, LMU München, 80336 Munich, Germany.

Ivan Noreña (I)

Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, 80802 Munich, Germany.

Simon Winter (S)

Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, 80802 Munich, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, 80799 Munich, Germany.

Michael Hoelscher (M)

Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, 80802 Munich, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, 80799 Munich, Germany.
Center for International Health (CIH), LMU University Hospital, LMU Munich, 80336 Munich, Germany.
Unit Global Health, Helmholtz Zentrum München, German Research Centre for Environmental Health (HMGU), 85764 Neuherberg, Germany.
German Center for Infection Research (DZIF), Partner Site Munich, 80802 Munich, Germany.

Andreas Wieser (A)

Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, 80802 Munich, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, 80799 Munich, Germany.
German Center for Infection Research (DZIF), Partner Site Munich, 80802 Munich, Germany.
Max Von Pettenkofer Institute, Faculty of Medicine, LMU Munich, 80336 Munich, Germany.

Helmut Küchenhoff (H)

Statistical Consulting Unit StaBLab, Department of Statistics, LMU Munich, 80539 Munich, Germany.

Noemi Castelletti (N)

Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, 80802 Munich, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, 80799 Munich, Germany.
Institute of Radiation Medicine, Helmholtz Zentrum München, 85764 Neuherberg, Germany.

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Classifications MeSH