Programmable Artificial Skins Accomplish Antiscar Healing with Multiple Appendage Regeneration.
DNA supramolecular hydrogel
microenvironment
scar
skin appendage regeneration
wound healing
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
25 Oct 2024
25 Oct 2024
Historique:
revised:
21
08
2024
received:
22
05
2024
medline:
26
10
2024
pubmed:
26
10
2024
entrez:
26
10
2024
Statut:
aheadofprint
Résumé
Functional appendage regeneration is essential for skin rehabilitation, but it has always failed by current existing healing approaches, owing to their inefficacy in preventing disfiguring scars. In this study, a novel regeneration-directing artificial skin (RDAS) system is presented, which is based on the rational design of multi-layered hydrogels that closely mimic natural skin matrices. By leveraging the programmability and architectural rigidity of DNA components, without the need for exogenous cell transplantation, such RDAS effectively minimizes tissue fibrosis by accurately guiding the regenerative process in wound fibroblasts, enabling rapid scarless wound repair, restoration of dermal function, and successful in situ regeneration of multiple appendages, such as hair follicles (HFs), sebaceous glands (SGs), and sweat glands (SwGs). Therefore, the RDAS offers a cell-free antiscarring therapeutic strategy for regenerative wound healing, resulting in improved outcomes. This innovative approach holds great potential for future clinical applications and burn rehabilitation.
Identifiants
pubmed: 39460410
doi: 10.1002/adma.202407322
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2407322Subventions
Organisme : National Natural Science Foundation of China
ID : 92268206
Organisme : National Basic Research Plan of China
ID : 2023YFA0915201
Organisme : Beijing Municipal Science & Technology Commission and Zhongguancun Science Park Administrative Committee
ID : Z231100007223003
Organisme : CAMS Innovation Fund for Medical Sciences
ID : CIFMS 2019-I2M-5-059
Organisme : Military Medical Research Projects
ID : 2023-JSKY-SSQG-006
Organisme : Independent Research Project of State Key Laboratory of Trauma and Chemical Poisoning
Organisme : National Key Research and Development Program of China
ID : 2023YFC3011900
Organisme : Specific Research Fund of The Innovation Platform for Academicians of Hainan Province
ID : YSPTZX202317
Informations de copyright
© 2024 Wiley‐VCH GmbH.
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